POU4F3 and PLA2G10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POU4F3	PLA2G10
Description		POU class 4 homeobox 3	phospholipase A2 group X
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Visual Perception Sensory Perception Of Sound Vestibulocochlear Nerve Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Axon Extension Inner Ear Development Neuromuscular Process Controlling Balance Neuron Apoptotic Process Inner Ear Receptor Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Prostaglandin Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Axon Guidance Fertilization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonate Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Hair Follicle Morphogenesis Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Intestinal Stem Cell Homeostasis Macrophage Activation Cholesterol Homeostasis Regulation Of Macrophage Activation Erythrocyte Maturation Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonate Secretion Negative Regulation Of Cholesterol Efflux Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Acrosome Reaction
Pathways			Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs			Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases		Deafness, autosomal dominant
GWAS		PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Cholesteryl ester levels ( 31551469)
Interacting Genes		7 interacting genes: AURKA DUSP21 GOLGA2 KRT31 KRTAP6-3 NHLRC4 PLA2G10	55 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXA1 HOXC8 HR HSF4 INCA1 KPRP KRTAP10-8 KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE1F LCE2A LCE2B LCE2D LCE3A LCE5A MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 PLSCR4 POU4F3 ROR2 SAXO4 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10
Entrez ID		5459	8399
HPRD ID		03911	04674
Ensembl ID		ENSG00000091010	ENSG00000069764
Uniprot IDs		Q15319	O15496
PDB IDs			1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Assembly Meiotic Spindle Organization Negative Regulation Of Protein Binding Regulation Of Protein Binding Centrosome Cycle Mitotic Spindle Organization Organelle Disassembly Microtubule Organizing Center Organization Spindle Assembly Positive Regulation Of Reproductive Process Platelet Activating Factor Catabolic Process Reproductive Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Oocyte Maturation Lysophospholipid Transport Positive Regulation Of Protein Glycosylation Mitotic Spindle Spindle Pole Cytoskeleton Intermediate Filament Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Spindle Organization Golgi Disassembly Regulation Of Reproductive Process Chromosome Passenger Complex Mitotic Centrosome Separation Regulation Of Arachidonate Secretion Intestinal Stem Cell Homeostasis Positive Regulation Of Arachidonate Secretion Regulation Of Protein Glycosylation Pronucleus Axon Hillock 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Positive Regulation Of Protein Metabolic Process Microtubule-based Process Positive Regulation Of Cell Maturation Platelet Activating Factor Metabolic Process Positive Regulation Of Acrosome Reaction Importin-alpha Family Protein Binding Golgi Ribbon Formation Golgi Cis Cisterna Membraneless Organelle Assembly Asymmetric Cell Division Cilium Disassembly Centrosome Separation Spindle Assembly Involved In Female Meiosis Calcium-dependent Phospholipase A2 Activity Phosphatidylcholine Catabolic Process	Keratinization Epidermis Development Tissue Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Protein Binding Chromatin
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