POU4F3 and NHLRC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POU4F3	NHLRC4
Description		POU class 4 homeobox 3	NHL repeat containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Visual Perception Sensory Perception Of Sound Vestibulocochlear Nerve Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Axon Extension Inner Ear Development Neuromuscular Process Controlling Balance Neuron Apoptotic Process Inner Ear Receptor Cell Differentiation
Pathways
Drugs
Diseases		Deafness, autosomal dominant
GWAS		PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Mean corpuscular hemoglobin concentration ( 27863252)
Interacting Genes		7 interacting genes: AURKA DUSP21 GOLGA2 KRT31 KRTAP6-3 NHLRC4 PLA2G10	20 interacting genes: CERK DDIT4L DMRT3 DTX2 ENKD1 HSF4 IGFN1 KRTAP13-2 KRTAP15-1 KRTAP26-1 MGAT5B MYLIP OTX1 PATZ1 PITX1 POGZ POU4F3 PRKAB2 SPAG8 TLX3
Entrez ID		5459	283948
HPRD ID		03911	11681
Ensembl ID		ENSG00000091010	ENSG00000257108
Uniprot IDs		Q15319	P0CG21
PDB IDs
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Assembly Meiotic Spindle Organization Negative Regulation Of Protein Binding Regulation Of Protein Binding Centrosome Cycle Mitotic Spindle Organization Organelle Disassembly Microtubule Organizing Center Organization Spindle Assembly Positive Regulation Of Reproductive Process Platelet Activating Factor Catabolic Process Reproductive Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Oocyte Maturation Lysophospholipid Transport Positive Regulation Of Protein Glycosylation Mitotic Spindle Spindle Pole Cytoskeleton Intermediate Filament Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Spindle Organization Golgi Disassembly Regulation Of Reproductive Process Chromosome Passenger Complex Mitotic Centrosome Separation Regulation Of Arachidonate Secretion Intestinal Stem Cell Homeostasis Positive Regulation Of Arachidonate Secretion Regulation Of Protein Glycosylation Pronucleus Axon Hillock 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Positive Regulation Of Protein Metabolic Process Microtubule-based Process Positive Regulation Of Cell Maturation Platelet Activating Factor Metabolic Process Positive Regulation Of Acrosome Reaction Importin-alpha Family Protein Binding Golgi Ribbon Formation Golgi Cis Cisterna Membraneless Organelle Assembly Asymmetric Cell Division Cilium Disassembly Centrosome Separation Spindle Assembly Involved In Female Meiosis Calcium-dependent Phospholipase A2 Activity Phosphatidylcholine Catabolic Process	Sequence-specific Double-stranded DNA Binding Chromatin DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Diencephalon Morphogenesis Neuron Fate Specification Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Intermediate Filament
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