POU4F3 and DUSP21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POU4F3	DUSP21
Description		POU class 4 homeobox 3	dual specificity phosphatase 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytoskeleton Cilium Membrane Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Visual Perception Sensory Perception Of Sound Vestibulocochlear Nerve Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Axon Extension Inner Ear Development Neuromuscular Process Controlling Balance Neuron Apoptotic Process Inner Ear Receptor Cell Differentiation	Flagellated Sperm Motility Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs
Diseases		Deafness, autosomal dominant
GWAS		PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		7 interacting genes: AURKA DUSP21 GOLGA2 KRT31 KRTAP6-3 NHLRC4 PLA2G10	33 interacting genes: APP ATP23 BPIFA1 CPNE7 CTBP2 EPHA3 EPHA5 ERBB3 ERBB4 EYA2 FAAP20 GET4 GORASP2 IGF1R KLHL20 KRT33B KRTAP11-1 MAP2K5 MYO15B OIP5 POU4F3 PTK7 RFX6 RGS2 ROR1 ROR2 SUOX TEX11 TOX3 TRAF1 UBQLN2 USP2 ZMAT1
Entrez ID		5459	63904
HPRD ID		03911	06494
Ensembl ID		ENSG00000091010	ENSG00000189037
Uniprot IDs		Q15319	Q9H596
PDB IDs
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Assembly Meiotic Spindle Organization Negative Regulation Of Protein Binding Regulation Of Protein Binding Centrosome Cycle Mitotic Spindle Organization Organelle Disassembly Microtubule Organizing Center Organization Spindle Assembly Positive Regulation Of Reproductive Process Platelet Activating Factor Catabolic Process Reproductive Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Oocyte Maturation Lysophospholipid Transport Positive Regulation Of Protein Glycosylation Mitotic Spindle Spindle Pole Cytoskeleton Intermediate Filament Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Spindle Organization Golgi Disassembly Regulation Of Reproductive Process Chromosome Passenger Complex Mitotic Centrosome Separation Regulation Of Arachidonate Secretion Intestinal Stem Cell Homeostasis Positive Regulation Of Arachidonate Secretion Regulation Of Protein Glycosylation Pronucleus Axon Hillock 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Positive Regulation Of Protein Metabolic Process Microtubule-based Process Positive Regulation Of Cell Maturation Platelet Activating Factor Metabolic Process Positive Regulation Of Acrosome Reaction Importin-alpha Family Protein Binding Golgi Ribbon Formation Golgi Cis Cisterna Membraneless Organelle Assembly Asymmetric Cell Division Cilium Disassembly Centrosome Separation Spindle Assembly Involved In Female Meiosis Calcium-dependent Phospholipase A2 Activity Phosphatidylcholine Catabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Kinase Activity Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Neuregulin Receptor Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway GPI-linked Ephrin Receptor Activity Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Coreceptor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Glial Cell Development Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Cellular Developmental Process Insulin Receptor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Neuron Projection Guidance Axon Guidance ERBB2 Signaling Pathway Establishment Of Planar Polarity ATP Binding Epithelial Cell Differentiation Amyloid-beta Complex Apoptotic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Programmed Cell Death Positive Regulation Of Toll Signaling Pathway Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Heart Development Cranial Nerve Development Establishment Of Planar Polarity Involved In Nephron Morphogenesis Insulin-like Growth Factor Receptor Signaling Pathway Wnt-protein Binding Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Sulfite Oxidase Activity Type II Interferon Binding Meiotic Gene Conversion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?