WDR44 and SEC13

Number of citations: 0 (PubMedID 10747849)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		WDR44	SEC13
Name		WD repeat domain 44	SEC13 homolog, nuclear pore and COPII component
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Perinuclear Region Of Cytoplasm	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Nuclear Pore Outer Ring Cytoplasmic Vesicle GATOR2 Complex Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding Molecular Sequestering Activity	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Golgi To Plasma Membrane Protein Transport Positive Regulation Of Cilium Assembly Regulation Of Vesicle-mediated Transport Protein Localization To Cilium Cytosolic Ciliogenesis Negative Regulation Of Cilium Assembly	Protein Import Into Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Vesicle-mediated Transport Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Protein Exit From Endoplasmic Reticulum MRNA Transport COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		None	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly COPII-mediated vesicle transport MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation Amino acids regulate mTORC1 EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
GWAS		Trunk fat mass ( 28552196 )	Autism spectrum disorder or schizophrenia ( 28540026 )
Interacting Genes		5 interacting genes: CSNK2A1 GRB2 MSRA RAB11A SEC13	14 interacting genes: ADGRF5 CFAP43 CLDN12 EGFR HAPLN2 HSPB1 LTB4R2 NUP98 RAB11A SEC16B SEC31A TRAF5 WDR44 WEE2-AS1
Entrez ID		54521	6396
HPRD ID		11682	02538
Ensembl ID		ENSG00000131725	ENSG00000157020
Uniprot IDs		Q5JSH3	A8MWR8 P55735
PDB IDs		Not available	3BG0 3BG1 5A9Q 7PEQ 7R5J 7R5K 7UHY
GO Terms Enriched among Interactors		Establishment Of Protein Localization To Organelle Intracellular Protein Transport Guanyl-nucleotide Exchange Factor Adaptor Activity L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Synaptic Vesicle Endosomal Processing Protein Localization To Organelle Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Signal Transduction In Response To DNA Damage Extracellular Exosome Grb2-EGFR Complex Exosomal Secretion Regulation Of Early Endosome To Recycling Endosome Transport Protein Localization To Cleavage Furrow Organelle Organization Double-strand Break Repair Via Classical Nonhomologous End Joining Protein Transport Positive Regulation Of Aggrephagy Membraneless Organelle Assembly Intracellular Transport Cytosol Vesicle-mediated Transport Branching Involved In Labyrinthine Layer Morphogenesis Neurotrophin TRKA Receptor Binding Protein Repair Vesicle Organization Nuclear Pore Outer Ring COPII-coated Vesicle Budding GATOR2 Complex Plasma Membrane To Endosome Transport Positive Regulation Of Mitotic Cytokinetic Process Postsynaptic Recycling Endosome Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Astral Microtubule Organization Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Early Endosome To Recycling Endosome Transport Amyloid-beta Clearance By Transcytosis Presynaptic Endosome Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Regulation Of Protein Localization To Centrosome Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Establishment Of Protein Localization Insulin Receptor Substrate Binding Positive Regulation Of Mitotic Cytokinesis Aggrephagy Protein Targeting To Vacuole Involved In Autophagy	Regulation Of Protein Kinase C Signaling Establishment Of Protein Localization Golgi Vesicle Transport Cellular Localization Protein Transport Endoplasmic Reticulum Exit Site Golgi To Plasma Membrane Protein Transport Positive Regulation Of Cilium Assembly