SEC13 and CLDN12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SEC13	CLDN12
Description		SEC13 homolog, nuclear pore and COPII component	claudin 12
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Nuclear Pore Outer Ring Cytoplasmic Vesicle GATOR2 Complex Extracellular Exosome	Plasma Membrane Bicellular Tight Junction Membrane Lateral Plasma Membrane Tight Junction Anchoring Junction Cell Periphery
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Vesicle-mediated Transport Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Protein Exit From Endoplasmic Reticulum MRNA Transport COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Maintenance Of Blood-brain Barrier Tight Junction Assembly
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly COPII-mediated vesicle transport MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation Amino acids regulate mTORC1 EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Tight junction interactions
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		14 interacting genes: ADGRF5 CFAP43 CLDN12 EGFR HAPLN2 HSPB1 LTB4R2 NUP98 RAB11A SEC16B SEC31A TRAF5 WDR44 WEE2-AS1	4 interacting genes: ECHS1 SEC13 STRN4 TRARG1
Entrez ID		6396	9069
HPRD ID		02538	13064
Ensembl ID		ENSG00000157020	ENSG00000157224
Uniprot IDs		A8MWR8 P55735	B2R687 P56749
PDB IDs		3BG0 3BG1 5A9Q 7PEQ 7R5J 7R5K 7UHY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase C Signaling Establishment Of Protein Localization Golgi Vesicle Transport Cellular Localization Protein Transport Endoplasmic Reticulum Exit Site Golgi To Plasma Membrane Protein Transport Positive Regulation Of Cilium Assembly	3-hydroxypropionyl-CoA Dehydratase Activity Crotonyl-CoA Hydratase Activity Enoyl-CoA Hydratase Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity Vesicle Organization Nuclear Pore Outer Ring COPII-coated Vesicle Budding GATOR2 Complex Armadillo Repeat Domain Binding Glucose Import In Response To Insulin Stimulus Vesicle Fusion To Plasma Membrane Branched-chain Amino Acid Catabolic Process COPII-coated Vesicle Cargo Loading COPII Vesicle Coat Regulation Of Modification Of Synaptic Structure FAR/SIN/STRIPAK Complex Regulation Of Modification Of Postsynaptic Structure Endosome To Plasma Membrane Protein Transport D-glucose Import Branched-chain Amino Acid Metabolic Process Intracellular Protein Transport Negative Regulation Of Hippo Signaling Membrane Organization Protein Exit From Endoplasmic Reticulum Vesicle Budding From Membrane Vesicle Cargo Loading Protein Phosphatase 2A Binding D-glucose Transmembrane Transport Hexose Transmembrane Transport
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