SEC13 and SEC16B

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		SEC13	SEC16B
Description		SEC13 homolog, nuclear pore and COPII component	SEC16 homolog B, endoplasmic reticulum export factor
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Nuclear Pore Outer Ring Cytoplasmic Vesicle GATOR2 Complex Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Intracellular Membrane-bounded Organelle Endoplasmic Reticulum Exit Site
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Vesicle-mediated Transport Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Protein Exit From Endoplasmic Reticulum MRNA Transport COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Peroxisome Organization Positive Regulation Of Gene Expression Protein Transport Vesicle-mediated Transport Peroxisome Fission Positive Regulation Of Protein Exit From Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Exit Site
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly COPII-mediated vesicle transport MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation Amino acids regulate mTORC1 EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	COPII-mediated vesicle transport
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Adolescent idiopathic scoliosis ( 31417091) Adult body size ( 32376654) Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bitter non-alcoholic beverage consumption ( 31046077) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body composition traits ( 30026463) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 28448500 28552196 28892062 29273807 29381148 31453325 26961502 19079260 31513605 23669352 23583978 24861553 23563607 25673413 26426971 20935630) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005 26604143) Coffee consumption ( 31046077) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Epigenetic age acceleration in alcohol use disorder ( 31466081) Hand grip strength ( 29691431) Hip circumference ( 28552196 25673412) HOMA-B (corrected for HOMA-IR) ( 30369944) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Major depressive disorder ( 27479909) Meat-related diet ( 32066663) Menarche (age at onset) ( 21102462 25231870 27182965) Metabolic syndrome ( 31589552) Night sleep phenotypes ( 27126917) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (extreme) ( 30677029) Schizophrenia ( 23894747 30285260) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 32499647 30297969) Waist circumference ( 25673412 31453325 28552196) Waist circumference variance ( 31453325) Weight ( 28552196 19079260)
Interacting Genes		14 interacting genes: ADGRF5 CFAP43 CLDN12 EGFR HAPLN2 HSPB1 LTB4R2 NUP98 RAB11A SEC16B SEC31A TRAF5 WDR44 WEE2-AS1	3 interacting genes: FBXO7 SEC13 SRPK2
Entrez ID		6396	89866
HPRD ID		02538	11491
Ensembl ID		ENSG00000157020	ENSG00000120341
Uniprot IDs		A8MWR8 P55735	E9PK14 Q96JE7
PDB IDs		3BG0 3BG1 5A9Q 7PEQ 7R5J 7R5K 7UHY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase C Signaling Establishment Of Protein Localization Golgi Vesicle Transport Cellular Localization Protein Transport Endoplasmic Reticulum Exit Site Golgi To Plasma Membrane Protein Transport Positive Regulation Of Cilium Assembly	Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Neuron Apoptotic Process Nuclear Speck Organization Lewy Body Core COPII-coated Vesicle Budding Establishment Of Protein Localization To Organelle Nuclear Pore Outer Ring GATOR2 Complex R-loop Processing
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