CYP17A1 and ATP5E

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CYP17A1	ATP5E
Gene Name		cytochrome P450, family 17, subfamily A, polypeptide 1	ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Axon Neuronal Cell Body	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Core F(1) Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix
	Molecular Function	Steroid 17-alpha-monooxygenase Activity Iron Ion Binding Oxygen Binding Heme Binding 17-alpha-hydroxyprogesterone Aldolase Activity	ATPase Activity Transmembrane Transporter Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Steroid Biosynthetic Process Androgen Biosynthetic Process Glucocorticoid Biosynthetic Process Xenobiotic Metabolic Process Sex Differentiation Steroid Metabolic Process Response To Herbicide Response To Acetate Response To Ionizing Radiation Sterol Metabolic Process Response To Insecticide Biphenyl Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Phthalate Metabolic Process Hippocampus Development Adrenal Gland Development Ovulation Response To Nutrient Levels Response To Retinoic Acid Leydig Cell Differentiation Response To Cytokine Hormone Biosynthetic Process Progesterone Metabolic Process Response To Drug Small Molecule Metabolic Process Response To Steroid Hormone Response To CAMP Response To Methylmercury Oxidation-reduction Process Response To Fungicide Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Gonadotropin Stimulus Positive Regulation Of Steroid Hormone Biosynthetic Process	Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Proton Transport Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Glucocorticoid biosynthesis Metabolic disorders of biological oxidation enzymes Androgen biosynthesis Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The citric acid (TCA) cycle and respiratory electron transport Formation of ATP by chemiosmotic coupling
Drugs		NADH Progesterone Abiraterone
Diseases
GWAS		Blood pressure ( 21572416 21909110) Coronary heart disease ( 21378990) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Systolic blood pressure ( 19430479 19430483 21909115)
Protein-Protein Interactions		8 interactors: ATP5E BARX1 CDO1 CYB5A HSP90AB1 POR RPAIN TIGD7	1 interactors: CYP17A1
Entrez ID		1586	514
HPRD ID		01944	05856
Ensembl ID		ENSG00000148795
Uniprot IDs		P05093 Q1HB44	P56381
PDB IDs		2C17 3RUK 3SWZ
Enriched GO Terms of Interacting Partners?		Cellular Organofluorine Metabolic Process Nitrate Catabolic Process Nitric Oxide Catabolic Process Oxidation-reduction Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Taurine Biosynthetic Process Nitrate Metabolic Process L-cysteine Catabolic Process Hydrogen Ion Transmembrane Transport Proton Transport Positive Regulation Of Cholesterol Biosynthetic Process Taurine Metabolic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Cysteine Metabolic Process Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Cellular Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Organic Acid Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation L-ascorbic Acid Metabolic Process Carnitine Metabolic Process Negative Regulation Of Proteolysis Sulfur Amino Acid Catabolic Process Serine Family Amino Acid Catabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Positive Regulation Of Cell Size Negative Regulation Of Protein Processing Mitochondrial ATP Synthesis Coupled Proton Transport Amino-acid Betaine Metabolic Process Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Lipase Activity Regulation Of Cholesterol Biosynthetic Process Transport Regulation Of Protein Processing	Response To Acetate Response To Fungicide Phthalate Metabolic Process Glucocorticoid Biosynthetic Process Response To Herbicide Positive Regulation Of Steroid Hormone Biosynthetic Process Response To Methylmercury Dibenzo-p-dioxin Metabolic Process Biphenyl Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Androgen Biosynthetic Process Glucocorticoid Metabolic Process Response To Insecticide Leydig Cell Differentiation Cellular Response To Antibiotic Ovulation Progesterone Metabolic Process Cellular Response To Toxic Substance Cellular Response To Gonadotropin Stimulus Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process C21-steroid Hormone Metabolic Process Regulation Of Hormone Metabolic Process Androgen Metabolic Process Adrenal Gland Development Response To Gonadotropin Hormone Biosynthetic Process Response To Antibiotic Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Biosynthetic Process Hippocampus Development Cellular Ketone Metabolic Process Dicarboxylic Acid Metabolic Process Regulation Of Steroid Metabolic Process Phenol-containing Compound Metabolic Process Limbic System Development Female Gamete Generation Steroid Biosynthetic Process Response To CAMP Response To Retinoic Acid Sterol Metabolic Process Regulation Of Lipid Biosynthetic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Ionizing Radiation Response To Xenobiotic Stimulus Response To Organophosphorus Cellular Response To Lipopolysaccharide Male Gonad Development Cellular Response To Molecule Of Bacterial Origin
Tagcloud ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde pde11a pde2a pde3a pde3b pde4a pde4d phosphodiesterase select splicing xrn2
Tagcloud (Difference) ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde pde11a pde2a pde3a pde3b pde4a pde4d phosphodiesterase select splicing xrn2
Tagcloud (Intersection) ?