CYP2C19

Description		cytochrome P450 family 2 subfamily C member 19
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Metal Ion Binding (R)-limonene 6-monooxygenase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Epoxygenase P450 Pathway Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Omega-hydroxylase P450 Pathway
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aspirin ADME
Drugs		Isoniazid Benzbromarone
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Appendicular lean mass ( 33097823) Clopidogrel active metabolite levels ( 28207573) Clozapine-to-N-desmethylclozapine metabolic ratio in schizophrenia ( 32555152) Diastolic blood pressure ( 27618448 27841878) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean arterial pressure ( 27618448) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 19706858 28207573) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 30578418 27841878) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose ( 23755828)
Interacting Genes		1 interacting genes: POR
Entrez ID		1557
HPRD ID		00486
Ensembl ID		ENSG00000165841
Uniprot IDs		P33261
PDB IDs		4GQS
Enriched GO Terms of Interacting Partners?		Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Positive Regulation Of Steroid Hormone Biosynthetic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Demethylation Flavonoid Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Response To Follicle-stimulating Hormone FMN Binding Amino-acid Betaine Metabolic Process Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Chondrocyte Differentiation Cellular Response To Gonadotropin Stimulus Nitric Oxide Biosynthetic Process Regulation Of Hormone Biosynthetic Process Response To Gonadotropin Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Cartilage Development Regulation Of Hormone Metabolic Process Positive Regulation Of Steroid Biosynthetic Process NADP Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Steroid Metabolic Process Response To Dexamethasone Regulation Of Chondrocyte Differentiation Electron Transfer Activity Flavin Adenine Dinucleotide Binding Regulation Of Cartilage Development Enzyme Activator Activity Fatty Acid Oxidation Regulation Of Steroid Biosynthetic Process Lipid Oxidation Regulation Of Smoothened Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Electron Transport Chain Regulation Of Steroid Metabolic Process Xenobiotic Metabolic Process Response To Glucocorticoid Lipid Modification Intracellular Membrane-bounded Organelle Positive Regulation Of Lipid Metabolic Process
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