CYP1A2

Gene Name		cytochrome P450, family 1, subfamily A, polypeptide 2
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Electron Carrier Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Heme Binding Demethylase Activity Caffeine Oxidase Activity Aromatase Activity
	Biological Process	Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Toxin Biosynthetic Process Post-embryonic Development Alkaloid Metabolic Process Regulation Of Gene Expression Monoterpenoid Metabolic Process Drug Metabolic Process Dibenzo-p-dioxin Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Lung Development Methylation Response To Estradiol Response To Lipopolysaccharide Monocarboxylic Acid Metabolic Process Response To Immobilization Stress Drug Catabolic Process Exogenous Drug Catabolic Process Small Molecule Metabolic Process Cellular Respiration Heterocycle Metabolic Process Hydrogen Peroxide Biosynthetic Process Oxidation-reduction Process Oxidative Demethylation Cellular Response To Cadmium Ion Oxidative Deethylation Omega-hydroxylase P450 Pathway
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Aflatoxin activation and detoxification Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Phase II conjugation Xenobiotics Methylation Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Defective ACY1 causes encephalopathy
Drugs
Diseases
GWAS		Caffeine consumption ( 21490707) Coffee consumption ( 21876539 21357676) Diastolic blood pressure ( 19430483)
Protein-protein Interactions		2 interactors: CYB5A POR
Entrez ID		1544
HPRD ID		00489
Ensembl ID		ENSG00000140505
Uniprot IDs		P05177
PDB IDs		2HI4
Enriched GO Terms of Interacting Partners?		Cellular Organofluorine Metabolic Process Nitric Oxide Catabolic Process Nitrate Catabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitrate Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Hormone Biosynthetic Process L-ascorbic Acid Metabolic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Amino-acid Betaine Metabolic Process Negative Regulation Of Lipase Activity Regulation Of Cholesterol Biosynthetic Process Response To Follicle-stimulating Hormone Carboxylic Acid Metabolic Process Cellular Response To Gonadotropin Stimulus Flavonoid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Nitric Oxide Metabolic Process Organic Acid Metabolic Process Regulation Of Cholesterol Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Chondrocyte Differentiation Regulation Of Hormone Metabolic Process Positive Regulation Of Oxidoreductase Activity Response To Gonadotropin Positive Regulation Of Cartilage Development Positive Regulation Of Smoothened Signaling Pathway Oxidation-reduction Process Response To Cadmium Ion Positive Regulation Of Lipid Biosynthetic Process Demethylation Fatty Acid Oxidation Lipid Oxidation Regulation Of Chondrocyte Differentiation Regulation Of Steroid Biosynthetic Process Regulation Of Oxidoreductase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Water-soluble Vitamin Metabolic Process Regulation Of Cartilage Development Regulation Of Smoothened Signaling Pathway Regulation Of Steroid Metabolic Process Regulation Of Organ Growth Reactive Oxygen Species Metabolic Process Vitamin Metabolic Process
Tagcloud ?		alrt1057 alrt1550 coadministered cyp2b1 cyp3a cyp4a dawley differing elicit exerting glucuronidation isozymes lg100268 lgd1069 microsomal microsomes naturally p450 pan panretin retinoid retinoids rxr selectivities selectivity sprague targretin tretinoin