CCSER2 and KIFAP3

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		CCSER2	KIFAP3
Description		coiled-coil serine rich protein 2	kinesin associated protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Cytoskeleton	Condensed Nuclear Chromosome Photoreceptor Outer Segment Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Kinesin Complex Spindle Microtubule Cilium Axoneme Microtubule Cytoskeleton Kinesin II Complex Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Transition Zone Ciliary Basal Body Ciliary Tip Postsynapse Glutamatergic Synapse Periciliary Membrane Compartment
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Kinesin Binding Protein Phosphatase Binding Intraciliary Transport Particle B Binding
	Biological Process	Microtubule Bundle Formation	Apoptotic Process Microtubule-based Process Microtubule-based Movement Signal Transduction Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Intracellular Protein Localization Cell Population Proliferation Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Apoptotic Process Cilium Organization Positive Regulation Of Calcium-dependent Cell-cell Adhesion Protein-containing Complex Assembly Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Cerebrospinal P-tau181p levels ( 28247064) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Refractive error ( 32231278)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Adverse response to drug ( 30420678) Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 28416818) L-selectin levels ( 25576479) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: APP ATRX CRADD EXOC1 EXOSC8 GTF2H1 KIFAP3 MAP1LC3B OFD1 PSMD11 STX1A TCEA2	33 interacting genes: APC AR C19orf44 CCSER2 DHX37 DISC1 GTSE1 HOXB5 KANK2 KIF3B MAP3K10 MAP3K11 MARK2 MEST MINK1 MOS MYPOP NAA10 NAA11 NAV1 NCF2 NIPSNAP3A NUDT21 PARD6G PEX19 PRNP RAP1GDS1 RBFOX1 RBM14 RPGR RTP5 SMC3 SRC
Entrez ID		54462	22920
HPRD ID		13832	03499
Ensembl ID		ENSG00000107771	ENSG00000075945
Uniprot IDs		Q9H7U1	A0AAQ5BGI3 Q92845
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Axo-dendritic Transport Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Microtubule-based Transport Amylin Binding Endosome To Plasma Membrane Transport Vesicle Cellular Component Assembly Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Modulation Of Excitatory Postsynaptic Potential Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Post-embryonic Forelimb Morphogenesis Chromosome, Subtelomeric Region Vesicle Docking Involved In Exocytosis Membrane Docking Myosin Head/neck Binding Vesicle Docking Positive Regulation Of Norepinephrine Secretion Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Ciliary Basal Body Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Death Domain Binding Endopeptidase Complex U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Kinesin II Complex Positive Regulation Of Calcium-dependent Cell-cell Adhesion Calcium:proton Antiporter Activity Calcium Export From The Mitochondrion Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Microtubule-based Process Regulation Of Apoptotic Signaling Pathway	Microtubule-based Process Protein Autophosphorylation Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Cytoplasm Organelle Organization MAP Kinase Kinase Kinase Activity Protein N-terminal-serine Acetyltransferase Activity Cytoskeleton Organization ATPase Binding Microtubule Cytoskeleton Organization NatA Complex Microtubule Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity MAPK Cascade Regulation Of Protein Serine/threonine Kinase Activity Microtubule Binding Microtubule Cytoskeleton JUN Kinase Kinase Kinase Activity Negative Regulation Of Cell Cycle Process Membraneless Organelle Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Centrosome Positive Regulation Of MAPK Cascade JNK Cascade Positive Regulation Of JUN Kinase Activity N-terminal Protein Amino Acid Acetylation Regulation Of MAPK Cascade Protein Binding Cytoskeleton Organelle Assembly Protein Kinase Activity Intracellular Signal Transduction Lamin Binding Negative Regulation Of Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Cell Cycle Protein Serine Kinase Activity Angiotensin-activated Signaling Pathway Dynein Complex Binding Mitochondrial Calcium Ion Homeostasis Phosphorylation Protein Serine/threonine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity ATP Binding Kinase Activity Regulation Of Chromosome Organization
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