PON2 and HTR2A

Number of citations of the paper that reports this interaction (PMID 16537434)
10

Data Source:
HPRD (two hybrid)

		PON2	HTR2A
Gene Name		paraoxonase 2	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Mitochondrion Lysosome Plasma Membrane	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cytoplasmic Membrane-bounded Vesicle Axon Neuronal Cell Body Dendritic Shaft Cell Body Fiber
	Molecular Function	Arylesterase Activity Identical Protein Binding Metal Ion Binding	G-protein Alpha-subunit Binding Serotonin Receptor Activity Drug Binding Protein Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
	Biological Process	Response To Oxidative Stress Aromatic Compound Catabolic Process	Temperature Homeostasis Cellular Calcium Ion Homeostasis Activation Of Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Aging Memory Cell Death Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Sleep Response To Drug Negative Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Regulation Of Hormone Secretion Behavioral Response To Cocaine Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs			Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Pramipexole Promazine Cyproheptadine Imipramine Chlorpromazine Haloperidol Nortriptyline Lisuride Cisapride Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupenthixol Cyclobenzaprine Mesoridazine Promethazine Tegaserod Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Dihydroergotoxine Yohimbine Methotrimeprazine MMDA 3,4-Methylenedioxymethamphetamine Dimethyltryptamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Iloperidone Sertindole Mianserin Asenapine Amisulpride Cinitapride Lurasidone
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		2 interactors: GRB2 HTR2A	16 interactors: ANKS1B DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3
Entrez ID		5445	3356
HPRD ID		03903	01638
Ensembl ID		ENSG00000105854	ENSG00000102468
Uniprot IDs		J3QT77 Q15165	P28223
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Phospholipase C-activating Serotonin Receptor Signaling Pathway Aging Positive Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Phospholipid Biosynthetic Process Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Regulation Of MAPK Cascade Urinary Bladder Smooth Muscle Contraction Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Glycolytic Process Serotonin Receptor Signaling Pathway Vascular Smooth Muscle Contraction Behavioral Response To Cocaine Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Organonitrogen Compound Sleep Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cell-cell Signaling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Protein Localization To Cytoskeleton Regulation Of Dopamine Secretion Labyrinthine Layer Morphogenesis Negative Regulation Of Potassium Ion Transport Phosphatidylinositol 3-kinase Signaling Temperature Homeostasis Response To Abiotic Stimulus Regulation Of Glycolytic Process Embryonic Placenta Morphogenesis Detection Of Temperature Stimulus Negative Regulation Of Signaling Sensory Perception Of Temperature Stimulus Positive Regulation Of Vasoconstriction Vasoconstriction Positive Regulation Of Signal Transduction Release Of Sequestered Calcium Ion Into Cytosol Detection Of Mechanical Stimulus Involved In Sensory Perception Regulation Of Phosphorylation Regulation Of Sequestering Of Calcium Ion Receptor Internalization Calcium Ion Transport Into Cytosol Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cytosolic Calcium Ion Transport Detection Of Mechanical Stimulus Regulation Of Phosphorus Metabolic Process Negative Regulation Of ERBB Signaling Pathway Response To Cocaine Activation Of Phospholipase C Activity Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Phospholipase C Activity	Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Melanocyte Differentiation Response To Wounding Response To Stress Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Developmental Pigmentation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Platelet Activation Dopamine Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Neuron Differentiation Nucleotide Phosphorylation Phosphorylation Regulation Of Membrane Potential Histone H3-Y41 Phosphorylation Host Programmed Cell Death Induced By Symbiont Positive Regulation Of Axon Extension Involved In Regeneration Modulation By Virus Of Host Transcription Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Developmental Pigmentation Positive Regulation Of Insulin Secretion Response To Axon Injury Phosphate-containing Compound Metabolic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Glutamine Biosynthetic Process Mineralocorticoid Receptor Signaling Pathway Action Potential Interleukin-12-mediated Signaling Pathway Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Generation Of Neurons Positive Regulation Of Hormone Secretion Cell-cell Signaling Regulation Of Cell Differentiation Positive Regulation Of Synaptic Transmission Neuron Development Pigmentation Positive Regulation Of Cell Growth Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Neurogenesis Signaling Posttranscriptional Regulation Of Gene Expression Response To Organic Substance Cell Communication
Tagcloud ?		acyltransferase allozymes apoj apolipoproteins atherosclerotic catabolite cholesteryl conflicting equally gln hydrolase hydrolyze hydroperoxides incompletely incorporating insecticide lecithin leu lipoprotein lipoproteins originally paraoxon paraoxonase parathion phospholipids physiologic pon1 pon3	adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations
Tagcloud (Difference) ?		acyltransferase allozymes apoj apolipoproteins atherosclerotic catabolite cholesteryl conflicting equally gln hydrolase hydrolyze hydroperoxides incompletely incorporating insecticide lecithin leu lipoprotein lipoproteins originally paraoxon paraoxonase parathion phospholipids physiologic pon1 pon3	adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations
Tagcloud (Intersection) ?