PON2

Description		paraoxonase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Arylesterase Activity Protein Binding Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Acyl-L-homoserine-lactone Lactonohydrolase Activity
	Biological Process	Response To Toxic Substance Lactone Catabolic Process
Pathways		Synthesis of 5-eicosatetraenoic acids
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Yu-Zhi constitution type in type 2 diabetes ( 26169365)
Interacting Genes		2 interacting genes: GRB2 HTR2A
Entrez ID		5445
HPRD ID		03903
Ensembl ID		ENSG00000105854
Uniprot IDs		A0A0J9YXF2 Q15165
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Guanyl-nucleotide Exchange Factor Adaptor Activity Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of MAPK Cascade Regulation Of Cell-cell Adhesion Insulin Receptor Substrate Binding Grb2-EGFR Complex Regulation Of Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Synaptic Transmission, Glutamatergic G Protein-coupled Serotonin Receptor Complex Artery Smooth Muscle Contraction 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Sensory Perception Of Temperature Stimulus Serotonin Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Cell Body Fiber Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Urinary Bladder Smooth Muscle Contraction Nonassociative Learning Positive Regulation Of Platelet Aggregation Serotonin Receptor Signaling Pathway Tonic Smooth Muscle Contraction Positive Regulation Of Heat Generation Sensitization Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Activity Positive Regulation Of Phospholipid Biosynthetic Process Neurofilament Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Tyrosine Kinase Activator Activity Vascular Associated Smooth Muscle Contraction Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Behavioral Response To Cocaine Regulation Of Cell Adhesion Schwann Cell Development Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity Regulation Of Defense Response G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Positive Regulation Of Glycolytic Process Regulation Of Dopamine Secretion Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
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