GAR1 and SMN2

Number of citations of the paper that reports this interaction (PubMedID 11509230)
0

Data Source:
HPRD (in vitro, in vivo)

		GAR1	SMN2
Description		GAR1 ribonucleoprotein	survival of motor neuron 2, centromeric
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cajal Body Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies
	Molecular Function	RNA Binding Protein Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	SnoRNA Guided RRNA Pseudouridine Synthesis Pseudouridine Synthesis RRNA Processing Telomere Maintenance Via Telomerase Ribosome Biogenesis	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing
Pathways		Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs			Nusinersen
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes		7 interacting genes: DSCR9 FOXP1 NEAT1 PCBP2 SMN1 SMN2 UBC	37 interacting genes: BLOC1S6 BYSL CHTOP DDX20 DHX9 EHHADH FAM9B FBL FNDC11 GAR1 GEMIN2 HNRNPUL1 IQUB KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 MAGED1 MBD2 POLR1C POLR2A PPIG SMN1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNU13 SPANXN2 TIAL1 USP9X VPS28
Entrez ID		54433	6607
HPRD ID		07569	09036
Ensembl ID		ENSG00000109534	ENSG00000205571
Uniprot IDs		Q9NY12	B4DP61 E7EQZ4 Q16637
PDB IDs		7BGB 7TRC 7V9A 8OUE 8OUF	1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30
Enriched GO Terms of Interacting Partners?		SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex DNA-templated Transcription Termination MRNA Metabolic Process Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly RNA Binding Cajal Body RNA Splicing U6 2'-O-snRNA Methylation Cytoplasmic Ribonucleoprotein Granule MRNA Processing Positive Regulation Of Interleukin-21 Production Box C/D Sno(s)RNA 3'-end Processing MiRNA Inhibitor Activity Via Base-pairing RNA Metabolic Process Perikaryon Z Disc Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP RISC Complex Binding Positive Regulation Of Synoviocyte Proliferation LncRNA-mediated Post-transcriptional Gene Silencing Nucleoplasm Promoter-enhancer Loop Anchoring Activity Regulation Of Macrophage Colony-stimulating Factor Production SnRNA Modification Positive Regulation Of MiRNA Catabolic Process Viral RNA Genome Replication Osteoclast Development Regulation Of Endothelial Tube Morphogenesis Protein-RNA Complex Assembly Positive Regulation Of B Cell Receptor Signaling Pathway RNA Splicing, Via Transesterification Reactions Monocyte Activation Endothelial Cell Activation 7SK SnRNA Binding Positive Regulation Of Protein Localization To Cajal Body Paraspeckles Regulation Of MRNA Export From Nucleus IRES-dependent Viral Translational Initiation T Follicular Helper Cell Differentiation Regulation Of Defense Response RNA Processing Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development U6 SnRNA Binding Negative Regulation Of B Cell Apoptotic Process	SMN-Sm Protein Complex Spliceosomal SnRNP Assembly 7-methylguanosine Cap Hypermethylation Spliceosomal Complex Assembly U1 SnRNP U4 SnRNP Methylosome Protein-RNA Complex Assembly U2-type Prespliceosome Assembly RNA Splicing, Via Transesterification Reactions RNA Splicing U2 SnRNP U2-type Precatalytic Spliceosome U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Small Nuclear Ribonucleoprotein Complex U5 SnRNP U4/U6 X U5 Tri-snRNP Complex RNA Processing U12-type Spliceosomal Complex MRNA Processing PICln-Sm Protein Complex MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex MRNA Metabolic Process U7 SnRNP Precatalytic Spliceosome Spliceosomal Complex RNA Methylation RNA Metabolic Process Catalytic Step 2 Spliceosome RNA Binding RNA Modification Macromolecule Methylation Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Methylation Nucleoplasm Telomerase Holoenzyme Complex Protein-containing Complex Assembly Spliceosomal Tri-snRNP Complex Cellular Component Assembly Protein-containing Complex Organization Cytosol SMN Complex Gemini Of Cajal Bodies DNA-templated Transcription Termination Telomerase RNA Binding Intermediate Filament Histone Pre-mRNA DCP Binding
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