NR5A2 and SREBF1

Number of citations of the paper that reports this interaction (PubMedID 17283069)
0

Data Source:
BioGRID (pull down)

		NR5A2	SREBF1
Description		nuclear receptor subfamily 5 group A member 2	sterol regulatory element binding transcription factor 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm RNA Polymerase II Transcription Regulator Complex	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Protein Kinase Binding Sterol Response Element Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Primary Ovarian Follicle Growth Inner Cell Mass Cell Differentiation Positive Regulation Of T Cell Anergy Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Bile Acid Metabolic Process Hormone-mediated Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Tissue Development Neurogenesis Intracellular Receptor Signaling Pathway Exocrine Pancreas Development Positive Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Chondrocyte Differentiation Somatic Stem Cell Population Maintenance Embryonic Cleavage Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Homeostatic Process Cholesterol Homeostasis Positive Regulation Of Viral Genome Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Cartilage Development Sertoli Cell Development Pancreas Morphogenesis Acinar Cell Differentiation Calcineurin-mediated Signaling Morula Formation Zygotic Genome Activation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Tendon Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Rate By Chemical Signal Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Biosynthetic Process Response To Nutrient Circadian Rhythm Steroid Metabolic Process Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Glucose Response To Fructose Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Insulin Secretion Lung Development Intracellular Receptor Signaling Pathway Regulation Of Protein Stability Response To Food Response To Retinoic Acid Response To Progesterone Cellular Response To Insulin Stimulus SREBP Signaling Pathway Response To Glucagon Response To Lipid MRNA Transcription By RNA Polymerase II Response To Peptide Hormone Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Response To CAMP Response To Fatty Acid Cellular Response To Fatty Acid Negative Regulation Of Triglyceride Metabolic Process Regulation Of Mitophagy Positive Regulation Of MiRNA Transcription Regulation Of Protein Targeting To Mitochondrion
Pathways		Estrogen-dependent gene expression	Cholesterol biosynthesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs			Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
Diseases
GWAS		Age at voice drop ( 27182965) Cerebrospinal T-tau levels ( 28247064) Cervical high-risk human papilloma virus infection (persistent) ( 33225922) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepcidin/transferrin saturation ratio ( 27846281) Hyperinsulinemia in obesity ( 30327367) Hyperinsulinemia x BMI interaction ( 30327367) Inflammatory bowel disease ( 28067908) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Length of menstrual cycle ( 30202859) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30804560 30061609) Menarche (age at onset) ( 25231870) Myopia ( 27182965) Nicotine dependence ( 28440896) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Pancreatic cancer ( 29422604 20101243 25086665 27579533 26098869) Refractive error ( 32231278) Rheumatoid arthritis ( 25014791) Ulcerative colitis ( 28067908) Uric acid levels ( 21294900) Urinary albumin excretion ( 30220432)	Coffee consumption ( 31046077) Eosinophil count ( 32888494) Hip index ( 34021172) Lymphocyte count ( 32888494) Parkinson's disease ( 21738487) Resting heart rate ( 27798624) Schizophrenia ( 25056061 28991256 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: ALB BCKDK CTNNB1 DDB2 EDF1 FTH1 GTF2H2C HSP90B1 NCOA1 NCOA3 NPPA NR0B2 NR1I2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 RANBP2 SMARCD3 SREBF1 UBE2I	42 interacting genes: AR ATXN1 ATXN1L CDK8 CREBBP DDX39B EP300 ESR1 ESR2 GSK3B HNF4A ID2 ID3 KLF13 LMNA MAPK1 MAPK3 MECOM MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 MTNR1B NR0B1 NR5A2 PLK1 PRMT5 SMARCC1 SMARCD3 SP1 SUMO1 TWIST2 UBE2I YY1 ZBTB7C
Entrez ID		2494	6720
HPRD ID		06830	01701
Ensembl ID		ENSG00000116833	ENSG00000072310
Uniprot IDs		F1D8R9 O00482	B3KR77 P36956
PDB IDs		1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8 4ONI 4PLD 4PLE 4RWV 5L0M 5L11 5SYZ 5UNJ 6OQX 6OQY 6OR1 6VC2 6VIF 7JYD 7JYE 7TT8 8F8M 8PKI	1AM9
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Nucleus Nuclear Estrogen Receptor Binding Transcription Coregulator Binding Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Transcription Coregulator Activity Positive Regulation Of RNA Metabolic Process Transcription Coactivator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Nuclear Thyroid Hormone Receptor Binding Acinar Cell Differentiation Regulation Of Metabolic Process SUMO Ligase Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Response To Estradiol Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Primary Metabolic Process Rhythmic Process Regulation Of Neuroblast Proliferation Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Neuron Fate Determination Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Protein-containing Complex Binding Nucleobase-containing Compound Biosynthetic Process Lens Morphogenesis In Camera-type Eye Hypothalamus Development Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Mediator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Core Mediator Complex Positive Regulation Of Transcription Initiation By RNA Polymerase II Nucleus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Initiation Transcription Coregulator Activity Transcription Preinitiation Complex Assembly Transcription Coactivator Activity Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Vitamin D Receptor Binding Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Somatic Stem Cell Population Maintenance Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Rhythmic Process
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