NR5A2 and PNRC2

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NR5A2	PNRC2
Description		nuclear receptor subfamily 5 group A member 2	proline rich nuclear receptor coactivator 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm RNA Polymerase II Transcription Regulator Complex	P-body Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Primary Ovarian Follicle Growth Inner Cell Mass Cell Differentiation Positive Regulation Of T Cell Anergy Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Bile Acid Metabolic Process Hormone-mediated Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Tissue Development Neurogenesis Intracellular Receptor Signaling Pathway Exocrine Pancreas Development Positive Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Chondrocyte Differentiation Somatic Stem Cell Population Maintenance Embryonic Cleavage Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Homeostatic Process Cholesterol Homeostasis Positive Regulation Of Viral Genome Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Cartilage Development Sertoli Cell Development Pancreas Morphogenesis Acinar Cell Differentiation Calcineurin-mediated Signaling Morula Formation Zygotic Genome Activation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Tendon Cell Differentiation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways		Estrogen-dependent gene expression	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Cerebrospinal T-tau levels ( 28247064) Cervical high-risk human papilloma virus infection (persistent) ( 33225922) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepcidin/transferrin saturation ratio ( 27846281) Hyperinsulinemia in obesity ( 30327367) Hyperinsulinemia x BMI interaction ( 30327367) Inflammatory bowel disease ( 28067908) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Length of menstrual cycle ( 30202859) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30804560 30061609) Menarche (age at onset) ( 25231870) Myopia ( 27182965) Nicotine dependence ( 28440896) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Pancreatic cancer ( 29422604 20101243 25086665 27579533 26098869) Refractive error ( 32231278) Rheumatoid arthritis ( 25014791) Ulcerative colitis ( 28067908) Uric acid levels ( 21294900) Urinary albumin excretion ( 30220432)	Obesity-related traits ( 23251661)
Interacting Genes		24 interacting genes: ALB BCKDK CTNNB1 DDB2 EDF1 FTH1 GTF2H2C HSP90B1 NCOA1 NCOA3 NPPA NR0B2 NR1I2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 RANBP2 SMARCD3 SREBF1 UBE2I	23 interacting genes: APP AR BANP DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GALK1 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48
Entrez ID		2494	55629
HPRD ID		06830	17871
Ensembl ID		ENSG00000116833	ENSG00000189266
Uniprot IDs		F1D8R9 O00482	Q9NPJ4
PDB IDs		1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8 4ONI 4PLD 4PLE 4RWV 5L0M 5L11 5SYZ 5UNJ 6OQX 6OQY 6OR1 6VC2 6VIF 7JYD 7JYE 7TT8 8F8M 8PKI	4B6H 5KQ1 5KQ4
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Nucleus Nuclear Estrogen Receptor Binding Transcription Coregulator Binding Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Transcription Coregulator Activity Positive Regulation Of RNA Metabolic Process Transcription Coactivator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Nuclear Thyroid Hormone Receptor Binding Acinar Cell Differentiation Regulation Of Metabolic Process SUMO Ligase Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Response To Estradiol Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Primary Metabolic Process Rhythmic Process Regulation Of Neuroblast Proliferation Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Neuron Fate Determination Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Protein-containing Complex Binding Nucleobase-containing Compound Biosynthetic Process Lens Morphogenesis In Camera-type Eye Hypothalamus Development Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity	Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of RNA Metabolic Process Estrogen Response Element Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Steroid Receptor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Zinc Ion Binding Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Developmental Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Transcription Coactivator Binding Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Transcription Cis-regulatory Region Binding Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Estrogen Stimulus Regulation Of Cell Differentiation Cellular Response To Lipid
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