NDOR1 and GPS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NDOR1	GPS2
Description		NADPH dependent diflavin oxidoreductase 1	G protein pathway suppressor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Transcription Repressor Complex
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding Electron Transfer Activity FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Flavin Adenine Dinucleotide Binding NADP Binding NADPH Binding FAD Binding NADPH-iron-sulfur [2Fe-2S] Protein Oxidoreductase Activity	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding
	Biological Process	Iron-sulfur Cluster Assembly Electron Transport Chain	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways		Cytosolic iron-sulfur cluster assembly	PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		29 interacting genes: C7orf57 CCDC33 CENATAC CYCS DLG4 DRC4 EFHC2 ENOX2 GPS2 HOXB2 KIAA0408 LMO2 LMO3 LNX1 MEOX1 MTUS2 NAB2 NLK PSMB6 TCF4 TCHP TEPSIN TLE5 UBQLN1 UBQLN2 ZBTB42 ZC2HC1C ZNF620 ZNF774	53 interacting genes: ACTMAP AKAP8L ATF4 ATF5 BAG4 BRME1 CCNA1 CHD3 CNOT2 CYSRT1 DAZAP2 EP300 FAM168B FHL5 GOLGA2 HDAC1 HDAC3 HNRNPH1 HOXA1 INTS11 KRT27 KRT31 KRT34 KRT36 KRTAP11-1 KRTAP13-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 MAP3K7CL NCOR1 NDOR1 NR0B2 OIP5 PBK POU2AF1 PRMT6 PRR22 RBPMS SESTD1 SETDB1 SMUG1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53 TP53BP2 TRIP6 UBTD2 VPS37C
Entrez ID		27158	2874
HPRD ID		10444	11878
Ensembl ID		ENSG00000188566	ENSG00000132522
Uniprot IDs		Q9UHB4	Q13227
PDB IDs		4H2D	2L5G
Enriched GO Terms of Interacting Partners?			Intermediate Filament Keratin Filament Circadian Rhythm Transcription Repressor Complex Structural Molecule Activity Histone Deacetylase Complex Rhythmic Process Transcription Cis-regulatory Region Binding P53 Binding NF-kappaB Binding Transcription Corepressor Binding Protein Binding Protein Lysine Delactylase Activity Cytosol Structural Constituent Of Skin Epidermis Circadian Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Transcription Corepressor Activity Histone Deacetylase Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Tissue Development Promoter-specific Chromatin Binding Mitotic Spindle Intermediate Filament Organization Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Androgen Receptor Signaling Pathway Cellular Response To UV Organelle Organization Negative Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Negative Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression DNA-binding Transcription Factor Binding Chromatin Organization Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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