CYC1 and CYCS

Number of citations of the paper that reports this interaction (PubMedID 6262312)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		CYC1	CYCS
Description		cytochrome c1	cytochrome c, somatic
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Apoptosome
	Molecular Function	Protein Binding Quinol-cytochrome-c Reductase Activity Electron Transfer Activity Heme Binding Metal Ion Binding	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Response To Glucagon Cellular Respiration Proton Transmembrane Transport	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic Process Cellular Respiration Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		Mitochondrial protein import Respiratory electron transport Complex III assembly Complex III assembly	Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Pyroptosis TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity Cytoprotection by HMOX1
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2	Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol
Diseases			Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Asthma ( 31959851) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)	Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)
Interacting Genes		3 interacting genes: CYCS GRSF1 UQCRFS1	22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2
Entrez ID		1537	54205
HPRD ID		00480	00479
Ensembl ID		ENSG00000179091	ENSG00000172115
Uniprot IDs		P08574	G4XXL9 P99999
PDB IDs		5XTE 5XTH 5XTI	1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ 6XNK
Enriched GO Terms of Interacting Partners?		Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Electron Transport Chain Aerobic Respiration Respiratory Electron Transport Chain Aerobic Electron Transport Chain Cellular Respiration Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Mitochondrial RNA Catabolic Process Apoptosome Mitochondrion Quinol-cytochrome-c Reductase Activity Generation Of Precursor Metabolites And Energy Mitochondrial RNA Catabolic Process G-quadruplex RNA Binding Mitochondrial Matrix Respiratory Chain Complex III Mitochondrial Respiratory Chain Complex III Assembly Mitochondrial Inner Membrane Ribonucleoprotein Granule Mitochondrial Electron Transport, Cytochrome C To Oxygen Morphogenesis Of Embryonic Epithelium 2 Iron, 2 Sulfur Cluster Binding Execution Phase Of Apoptosis Cytochrome Complex Assembly Mitochondrial RNA Metabolic Process Mitochondrial Nucleoid Electron Transfer Activity Iron-sulfur Cluster Binding	Electron Transport Chain Mitochondrial Outer Membrane Mitochondrion Neuron Apoptotic Process Generation Of Precursor Metabolites And Energy Mitochondrial Membrane Apoptosome Dendritic Cell Apoptotic Process Respiratory Electron Transport Chain Mitochondrial Membrane Organization Mitochondrion Organization Quinol-cytochrome-c Reductase Activity FAD Binding BH3 Domain Binding Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Epithelial Cell Apoptotic Process Leukocyte Apoptotic Process Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Bcl-2 Family Protein Complex Electron Transfer Activity Intrinsic Apoptotic Signaling Pathway Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Pore Complex Aerobic Electron Transport Chain Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Steroid Biosynthetic Process Mitochondrial Inner Membrane Response To Alkaloid Platelet Alpha Granule Membrane Aerobic Respiration Negative Regulation Of Anoikis Regulation Of Neuron Apoptotic Process Negative Regulation Of Autophagy Programmed Cell Death Involved In Cell Development Cellular Respiration Oxidative Phosphorylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Cytosol Positive Regulation Of Apoptotic Process Regulation Of Anoikis Ubiquitin Protein Ligase Binding Sterol Metabolic Process Protein Refolding Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway
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