NANS and BCL10

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		NANS	BCL10
Description		N-acetylneuraminate synthase	BCL10 immune signaling adaptor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Immunological Synapse Polkadots Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Membrane CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Transferase Activity N-acylneuraminate-9-phosphate Synthase Activity N-acetylneuraminate Synthase Activity	Protease Binding Transcription Coactivator Activity Protein Binding Kinase Activator Activity Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding General Transcription Initiation Factor Binding
	Biological Process	N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Carbohydrate Biosynthetic Process N-acetylneuraminate Biosynthetic Process Glycosylation	B Cell Apoptotic Process Positive Regulation Of Cytokine Production Neural Tube Closure Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Apoptotic Process Cellular Defense Response Response To Fungus Programmed Cell Death Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Antifungal Innate Immune Response T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Sialic acid metabolism	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)
Interacting Genes		19 interacting genes: APC AURKA BCL10 BUB1 CDH1 CTNNA1 EGFR FBXO7 FBXW7 FLCN MCC MLH3 MSH6 ODC1 PDGFRL PTPRJ SRC STK11 TLR2	45 interacting genes: AKT1 ANP32B ATM BAAT CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NHERF1 NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1
Entrez ID		54187	8915
HPRD ID		07285	04625
Ensembl ID		ENSG00000095380	ENSG00000142867
Uniprot IDs		Q9NR45	A0A087WWW9 A2TDT2 O95999
PDB IDs		1WVO	2MB9 6BZE 6GK2 8CZD 8CZO
Enriched GO Terms of Interacting Partners?		Gamma-catenin Binding Regulation Of Protein Localization Cell Junction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Protein Modification Process Regulation Of Protein Localization To Nucleus Ubiquitin Protein Ligase Binding Negative Regulation Of Signal Transduction Cadherin Binding Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Communication Positive Regulation Of Catabolic Process Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Catenin Complex Developmental Process Ruffle Membrane Beta-catenin Binding Negative Regulation Of Developmental Process Regulation Of Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Immune Response-activating Cell Surface Receptor Signaling Pathway Cell-cell Junction Assembly Cell Junction Assembly Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Cellular Response To Indole-3-methanol Regulation Of Apoptotic Process Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Response To Indole-3-methanol Regulation Of Developmental Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation	Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Modification Process CBM Complex Regulation Of Signal Transduction CARD Domain Binding Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of Signaling Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Pattern Recognition Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-2 Production Non-canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Innate Immune Response Positive Regulation Of Apoptotic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?