NANS

Description		N-acetylneuraminate synthase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Transferase Activity N-acylneuraminate-9-phosphate Synthase Activity N-acetylneuraminate Synthase Activity
	Biological Process	N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Carbohydrate Biosynthetic Process N-acetylneuraminate Biosynthetic Process Glycosylation
Pathways		Sialic acid metabolism
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Novel Interacting Genes		1 novel interacting genes: RFX3
Interacting Genes		19 interacting genes: APC AURKA BCL10 BUB1 CDH1 CTNNA1 EGFR FBXO7 FBXW7 FLCN MCC MLH3 MSH6 ODC1 PDGFRL PTPRJ SRC STK11 TLR2
Entrez ID		54187
HPRD ID		07285
Ensembl ID		ENSG00000095380
Uniprot IDs		Q9NR45
PDB IDs		1WVO
Enriched GO Terms of Interacting Partners?		Gamma-catenin Binding Regulation Of Protein Localization Cell Junction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Protein Modification Process Regulation Of Protein Localization To Nucleus Ubiquitin Protein Ligase Binding Negative Regulation Of Signal Transduction Cadherin Binding Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Communication Positive Regulation Of Catabolic Process Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Catenin Complex Developmental Process Ruffle Membrane Beta-catenin Binding Negative Regulation Of Developmental Process Regulation Of Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Immune Response-activating Cell Surface Receptor Signaling Pathway Cell-cell Junction Assembly Cell Junction Assembly Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Cellular Response To Indole-3-methanol Regulation Of Apoptotic Process Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Response To Indole-3-methanol Regulation Of Developmental Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation
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