NANS and ODC1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		NANS	ODC1
Description		N-acetylneuraminate synthase	ornithine decarboxylase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Transferase Activity N-acylneuraminate-9-phosphate Synthase Activity N-acetylneuraminate Synthase Activity	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity Protein Homodimerization Activity
	Biological Process	N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Carbohydrate Biosynthetic Process N-acetylneuraminate Biosynthetic Process Glycosylation	Kidney Development Polyamine Metabolic Process Polyamine Biosynthetic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Virus Putrescine Biosynthetic Process From Arginine, Via Ornithine Regulation Of Protein Catabolic Process
Pathways		Sialic acid metabolism	Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines
Drugs			Pyridoxal phosphate Spermine Sildenafil Valproic acid Putrescine Pyridoxine phosphate N-Pyridoxyl-Glycine-5-Monophosphate L-Eflornithine N(6)-(pyridoxal phosphate)-L-lysine Geneticin Eflornithine
Diseases
GWAS		Alopecia areata ( 25608926) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		19 interacting genes: APC AURKA BCL10 BUB1 CDH1 CTNNA1 EGFR FBXO7 FBXW7 FLCN MCC MLH3 MSH6 ODC1 PDGFRL PTPRJ SRC STK11 TLR2	17 interacting genes: BAAT CSNK2B GORASP2 HEMGN KAT5 MAP2K1 NANS OAZ1 OAZ2 RSC1A1 SSR1 STX17 TDRD7 TK1 TMOD1 TSTD2 ZNF510
Entrez ID		54187	4953
HPRD ID		07285	01324
Ensembl ID		ENSG00000095380	ENSG00000115758
Uniprot IDs		Q9NR45	B4DXF8 P11926
PDB IDs		1WVO	1D7K 2ON3 2OO0 4ZGY 5BWA 7S3F 7S3G 7U6P 7U6U 9B8M 9B8N
Enriched GO Terms of Interacting Partners?		Gamma-catenin Binding Regulation Of Protein Localization Cell Junction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Protein Modification Process Regulation Of Protein Localization To Nucleus Ubiquitin Protein Ligase Binding Negative Regulation Of Signal Transduction Cadherin Binding Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Communication Positive Regulation Of Catabolic Process Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Catenin Complex Developmental Process Ruffle Membrane Beta-catenin Binding Negative Regulation Of Developmental Process Regulation Of Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Immune Response-activating Cell Surface Receptor Signaling Pathway Cell-cell Junction Assembly Cell Junction Assembly Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Cellular Response To Indole-3-methanol Regulation Of Apoptotic Process Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Response To Indole-3-methanol Regulation Of Developmental Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation	Ornithine Decarboxylase Inhibitor Activity Negative Regulation Of Polyamine Transmembrane Transport Viral Translational Frameshifting Polyamine Biosynthetic Process Polyamine Metabolic Process Negative Regulation Of Transmembrane Transport Golgi Organization Viral Process Amine Biosynthetic Process Biogenic Amine Biosynthetic Process
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