POLE3 and SMARCA5

Number of citations of the paper that reports this interaction (PMID 14759371)
13

Data Source:
BioGRID (pull down)

		POLE3	SMARCA5
Gene Name		polymerase (DNA directed), epsilon 3, accessory subunit	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex	Condensed Chromosome Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus NURF Complex RSF Complex Nuclear Replication Fork
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	DNA Binding Helicase Activity Protein Binding ATP Binding ATPase Activity Nucleosome Binding Histone Binding
	Biological Process	DNA Replication Histone H3 Acetylation DNA Biosynthetic Process	Chromatin Silencing At RDNA Double-strand Break Repair Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleosome Positioning CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic
Pathways			NoRC negatively regulates rRNA expression Chromosome Maintenance Nucleosome assembly Deposition of new CENPA-containing nucleosomes at the centromere Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: APP BAZ1A CHRAC1 DR1 DRAP1 POLE POLE4 SMARCA5	17 interactors: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B H3F3A HDAC2 HIST1H3A HIST4H4 MAF POLE3 RAD21 RSF1 SATB1
Entrez ID		54107	8467
HPRD ID		06274	04538
Ensembl ID		ENSG00000148229	ENSG00000153147
Uniprot IDs		Q9NRF9	O60264
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Modification Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Biosynthetic Process DNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Remodeling Biosynthetic Process Histone H3 Acetylation Organelle Organization DNA-dependent DNA Replication Histone Acetylation Synaptic Growth At Neuromuscular Junction Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Collateral Sprouting In Absence Of Injury Cellular Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition RNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter Nucleosome Positioning Axon Choice Point Recognition Base-excision Repair, Gap-filling Gene Expression Neuron Remodeling Peptidyl-lysine Modification Negative Regulation Of Cellular Metabolic Process DNA Replication Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Chromatin Silencing At RDNA DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Cellular Copper Ion Homeostasis Regulation Of Transcription, DNA-templated Telomere Maintenance Via Semi-conservative Replication Regulation Of Nucleic Acid-templated Transcription	Chromatin Organization Chromatin Silencing Chromosome Organization Chromatin Remodeling Nucleobase-containing Compound Metabolic Process Chromatin Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization Negative Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Silencing Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Negative Regulation Of Gene Expression Chromatin Silencing At RDNA Negative Regulation Of Biosynthetic Process DNA Methylation Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Modification Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Chromatin Assembly DNA Packaging Histone Modification Methylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process DNA Conformation Change Fungiform Papilla Formation Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Regulation Of Metabolic Process Nucleosome Organization Fungiform Papilla Morphogenesis Protein-DNA Complex Assembly Transcription, DNA-templated Fungiform Papilla Development
Tagcloud ?		acetylase acetylating ada ada2 ada3 atac chrac17 coregulators fam48a gcn5 hereafter invertebrates machineries map3 map3k7 mbip nc2beta p38ip paralogous pole4 saga spt spt20 spt3 staf36 staga taf9 wdr5 yeats2	baz2a bc bladder characterizing fgfr3 formulation lowered messenger micrornas mir mirna mtor oncogenes oncogenesis oncomir ploidy promoted promoting qrt representative respective rnas rt4 supposed t24 thap2 today transfection urothelial
Tagcloud (Difference) ?		acetylase acetylating ada ada2 ada3 atac chrac17 coregulators fam48a gcn5 hereafter invertebrates machineries map3 map3k7 mbip nc2beta p38ip paralogous pole4 saga spt spt20 spt3 staf36 staga taf9 wdr5 yeats2	baz2a bc bladder characterizing fgfr3 formulation lowered messenger micrornas mir mirna mtor oncogenes oncogenesis oncomir ploidy promoted promoting qrt representative respective rnas rt4 supposed t24 thap2 today transfection urothelial
Tagcloud (Intersection) ?