PADI2 and PADI4

		PADI2	PADI4
Description		peptidyl arginine deiminase 2	peptidyl arginine deiminase 4
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GO Annotations	Cellular Component	Euchromatin Extracellular Region Nucleus Cytoplasm Cytosol Azurophil Granule Lumen Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Hydrolase Activity Nuclear Estrogen Receptor Binding Protein Homodimerization Activity Metal Ion Binding Histone Arginine Deiminase Activity Histone H3R26 Arginine Deiminase Activity	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Histone Arginine Deiminase Activity Histone H3R2 Arginine Deiminase Activity Histone H3R8 Arginine Deiminase Activity Histone H3R17 Arginine Deiminase Activity Histone H3R26 Arginine Deiminase Activity
	Biological Process	Chromatin Remodeling Substantia Nigra Development Estrogen Receptor Signaling Pathway Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Lymphocyte Chemotaxis Cellular Response To Leukemia Inhibitory Factor	Immune System Process Chromatin Organization Nucleosome Assembly Chromatin Remodeling Stem Cell Population Maintenance Protein Modification Process Post-translational Protein Modification Innate Immune Response
Pathways		Chromatin modifying enzymes Neutrophil degranulation	Chromatin modifying enzymes
Drugs		Citrulline	Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide Chlortetracycline
Diseases
GWAS		A body shape index ( 34021172) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Prudent dietary pattern ( 28644415) Rheumatoid arthritis ( 30423114) Visceral fat ( 30942860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 25305756 32912934) Rheumatoid arthritis ( 21452313 21505073 23143596 24390342 30423114 30572963 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		1 interacting genes: RIPK4	12 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 MDM2 NPM1 POU6F2 RYBP SMURF1 TRIB3
Entrez ID		11240	23569
HPRD ID		06396	05635
Ensembl ID		ENSG00000117115	ENSG00000159339
Uniprot IDs		Q9Y2J8	Q9UM07
PDB IDs		4N20 4N22 4N24 4N25 4N26 4N28 4N2A 4N2B 4N2C 4N2D 4N2E 4N2F 4N2G 4N2H 4N2I 4N2K 4N2L 4N2M 4N2N 9B96 9B97 9B98	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B 8GOD 8R8U 8R8V 8SMK 8SML
Enriched GO Terms of Interacting Partners?		Histone H3R8 Arginine Deiminase Activity Histone H3R17 Arginine Deiminase Activity Histone H3R2 Arginine Deiminase Activity Histone H3R26 Arginine Deiminase Activity Histone Arginine Deiminase Activity Protein-arginine Deiminase Activity Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence EMC Complex Membrane Insertase Activity Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into ER Membrane Protein-containing Complex	Positive Regulation Of Proteolysis Regulation Of Proteolysis Negative Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus Response To Catecholamine Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process NF-kappaB Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Dopamine Regulation Of Macromolecule Metabolic Process Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Manganese Ion Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Catabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Manganese Ion Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Golgi-associated Vesicle Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor Production Regulation Of RNA Metabolic Process Cellular Response To Reactive Oxygen Species Regulation Of Programmed Cell Death
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