PNLIPRP1 and BEST2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PNLIPRP1	BEST2
Description		pancreatic lipase related protein 1	bestrophin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Cilium Membrane Basolateral Plasma Membrane Chloride Channel Complex
	Molecular Function	Lipoprotein Lipase Activity Triacylglycerol Lipase Activity Calcium Ion Binding Protein Binding Phospholipase A1 Activity Lipase Activity Metal Ion Binding Carboxylic Ester Hydrolase Activity	Intracellularly Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Channel Activity Metal Ion Binding Ligand-gated Monoatomic Cation Channel Activity Ligand-gated Monoatomic Anion Channel Activity Bicarbonate Channel Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Catabolic Process High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis	Monoatomic Ion Transport Chloride Transport Sensory Perception Of Smell Bicarbonate Transport Monoatomic Ion Transmembrane Transport Membrane Depolarization Monoatomic Cation Transmembrane Transport Chloride Transmembrane Transport
Pathways		Digestion of dietary lipid	Stimuli-sensing channels
Drugs
Diseases
GWAS		Anger ( 24489884) Blood protein levels ( 30072576) Body mass index ( 26426971) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369)
Interacting Genes		45 interacting genes: AQP2 ARL13B BEST2 CD79A CERS4 CPLX4 CREB3 CYB5R3 EBP ERGIC3 FAM209A FFAR2 GDAP1 GJA8 GJB5 GPR152 GPR42 GPX8 HSD17B13 KCNJ6 LEUTX LMNA LRRC25 MCFD2 MEOX2 MUC1 NDUFAF1 NEMP1 PEX12 RETREG3 SCN3B SLC10A6 SLC16A2 SLC18A1 SLC34A2 SLC35H1 SLC39A2 SLC7A1 STX1A TMEM14B TMEM237 TMEM31 TMPPE TMX2 TSPAN8	16 interacting genes: CLDN10 COMT CYB561 DNAJC30 EFNA5 FXYD3 GPR25 MALL PNLIPRP1 RFT1 SLC61A1 SLC66A2 TMEM128 TMEM60 UNC93B1 UPK1B
Entrez ID		5407	54831
HPRD ID		05109	09548
Ensembl ID		ENSG00000187021	ENSG00000039987
Uniprot IDs		P54315	Q8NFU1
PDB IDs		2PPL	8D1E 8D1F 8D1G 8D1H 9DYH 9DYI 9DYJ 9DYK 9DYN 9DYO
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Protein Binding	Membrane Norepinephrine Secretion Catechol O-methyltransferase Activity Response To Food Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Lipid Translocation Regulation Of Membrane Lipid Distribution Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Glycolipid Translocation Glycolipid Floppase Activity
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