BEST2 and FXYD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BEST2	FXYD3
Description		bestrophin 2	FXYD domain containing ion transport regulator 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Basolateral Plasma Membrane Chloride Channel Complex	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Intracellularly Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Channel Activity Metal Ion Binding Ligand-gated Monoatomic Cation Channel Activity Ligand-gated Monoatomic Anion Channel Activity Bicarbonate Channel Activity	Chloride Channel Activity Protein Binding Sodium Channel Regulator Activity ATPase Binding Ion Channel Regulator Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Sensory Perception Of Smell Bicarbonate Transport Monoatomic Ion Transmembrane Transport Membrane Depolarization Monoatomic Cation Transmembrane Transport Chloride Transmembrane Transport	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Regulation Of Monoatomic Ion Transport Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane
Pathways		Stimuli-sensing channels	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS
Interacting Genes		16 interacting genes: CLDN10 COMT CYB561 DNAJC30 EFNA5 FXYD3 GPR25 MALL PNLIPRP1 RFT1 SLC61A1 SLC66A2 TMEM128 TMEM60 UNC93B1 UPK1B	64 interacting genes: AGR3 ANK1 AQP6 AQP9 BCL2L13 BEST2 CD79A CNR2 CREB3 CREB3L1 CYB5R3 EBP ERG28 ERGIC3 FAM209A FBXL12 FCGR2A FFAR2 GHITM GPR152 GPR37L1 GPR42 GPRC5D IBSP KASH5 KCNN4 LMNA LTC4S MAPK6 MFSD11 MGST1 MTIF3 NR4A1 NUDT3 PLPP6 SCN3B SERBP1 SGPL1 SLC10A1 SLC10A6 SLC16A12 SLC18A1 SLC1A1 SLC30A2 SLC35A1 SLC35B1 SLC35H1 SLC39A2 SLC61A1 SPNS3 STRIT1 STX3 TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM179B TMEM50B TMEM52B TMEM80 TMEM86A TMEM97 TSPO2 XKR3
Entrez ID		54831	5349
HPRD ID		09548	05410
Ensembl ID		ENSG00000039987	ENSG00000089356
Uniprot IDs		Q8NFU1	A0A1S5UZ23 Q14802 S4R445
PDB IDs		8D1E 8D1F 8D1G 8D1H 9DYH 9DYI 9DYJ 9DYK 9DYN 9DYO
Enriched GO Terms of Interacting Partners?		Membrane Norepinephrine Secretion Catechol O-methyltransferase Activity Response To Food Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Lipid Translocation Regulation Of Membrane Lipid Distribution Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Glycolipid Translocation Glycolipid Floppase Activity	Membrane Transmembrane Transport Endoplasmic Reticulum Membrane Organic Anion Transport Endoplasmic Reticulum Protein Binding Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Sterol Biosynthetic Process Monoatomic Ion Transport UDP-glucose Transmembrane Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Monoatomic Cation Transport Plasma Membrane Zinc Ion Transmembrane Transport Zinc Ion Transport Bile Acid:sodium Symporter Activity Inorganic Ion Transmembrane Transport Organic Hydroxy Compound Transport Steroid Biosynthetic Process Cholesterol Biosynthetic Process Metal Ion Transport Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Monoatomic Anion Channel Activity Monoatomic Ion Transmembrane Transport Channel Activity Inorganic Cation Transmembrane Transport Nuclear Membrane Monoatomic Cation Transmembrane Transport Antiporter Activity Amine Transport Negative Regulation Of Response To Endoplasmic Reticulum Stress
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