PNLIPRP1 and GJB5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PNLIPRP1	GJB5
Description		pancreatic lipase related protein 1	gap junction protein beta 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Lipoprotein Lipase Activity Triacylglycerol Lipase Activity Calcium Ion Binding Protein Binding Phospholipase A1 Activity Lipase Activity Metal Ion Binding Carboxylic Ester Hydrolase Activity	Gap Junction Channel Activity Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Catabolic Process High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis	Cell Communication Cell-cell Signaling Epidermis Development Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Morphogenesis
Pathways		Digestion of dietary lipid	Gap junction assembly
Drugs
Diseases
GWAS		Anger ( 24489884) Blood protein levels ( 30072576) Body mass index ( 26426971) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369)	BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Narcolepsy ( 23459209) Sleep duration (short sleep) ( 30846698) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		45 interacting genes: AQP2 ARL13B BEST2 CD79A CERS4 CPLX4 CREB3 CYB5R3 EBP ERGIC3 FAM209A FFAR2 GDAP1 GJA8 GJB5 GPR152 GPR42 GPX8 HSD17B13 KCNJ6 LEUTX LMNA LRRC25 MCFD2 MEOX2 MUC1 NDUFAF1 NEMP1 PEX12 RETREG3 SCN3B SLC10A6 SLC16A2 SLC18A1 SLC34A2 SLC35H1 SLC39A2 SLC7A1 STX1A TMEM14B TMEM237 TMEM31 TMPPE TMX2 TSPAN8	44 interacting genes: APOL2 APOL3 AQP1 ARLN C1GALT1 COMT CTXN3 CYB5B ERG28 FAM3C GSK3B IGFBP5 JAGN1 LMNA LPAR3 LRP10 MED1 MIP MS4A13 MYL2 NAPB PCGF2 PGAP2 PLPP4 PLPP6 PNLIPRP1 RPRM RTP2 SEC22A SEC22B SERP1 SLC30A2 SLC38A7 SLC41A1 SLC41A2 SMIM1 TM4SF4 TMEM128 TMEM60 TMEM86A TMEM97 TRIM2 TSPO2 VSTM1
Entrez ID		5407	2709
HPRD ID		05109	06840
Ensembl ID		ENSG00000187021	ENSG00000189280
Uniprot IDs		P54315	A0A654IE64 O95377
PDB IDs		2PPL
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Protein Binding	Membrane Monoatomic Cation Transmembrane Transporter Activity Endoplasmic Reticulum Membrane Protein Binding Neutrophil Differentiation Inorganic Cation Transmembrane Transporter Activity
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