QSOX1 and GPR52

Data Source: HiPPIP (Novel)

		QSOX1	GPR52
Name		quiescin sulfhydryl oxidase 1	G protein-coupled receptor 52
Structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Platelet Alpha Granule Lumen Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen	Plasma Membrane Membrane
	Molecular Function	Protein Disulfide Isomerase Activity Oxidoreductase Activity Flavin-dependent Sulfhydryl Oxidase Activity Thiol Oxidase Activity FAD Binding	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Photoreceptor Activity
	Biological Process	Protein Folding Negative Regulation Of Macroautophagy Extracellular Matrix Assembly	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phototransduction Locomotory Behavior Response To Xenobiotic Stimulus Detection Of Visible Light Cellular Response To Light Stimulus
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation	None
GWAS		Anorexia nervosa ( 23568457 ) Pulse pressure ( 30224653 30578418 )	No GWAS studies recorded
Novel Interactors		9 novel interactors: AKIP1 CREG1 GPR52 GREM2 KIF5B PHAF1 PRRX1 SERPINC1 TNR	1 novel interactors: QSOX1
Interacting Genes		7 interacting genes: BEGAIN CCR1 CCR6 CHRM4 SHANK3 UBE2D2 UBQLN4	1 interacting genes: POT1
Entrez ID		5768	9293
HPRD ID		06785	07247
Ensembl ID		ENSG00000116260	ENSG00000203737
Uniprot IDs		A0A140VKE5 O00391	F2YGU0 Q9Y2T5
PDB IDs		3LLI 3LLK 3Q6O 4IJ3	6LI0 6LI1 6LI2 6LI3 8HMP
GO Terms Enriched among Interactors		G Protein-coupled Receptor Activity Chemokine Receptor Activity Dendritic Cell Migration Dendritic Cell Chemotaxis C-C Chemokine Binding C-C Chemokine Receptor Activity Positive Regulation Of Synaptic Transmission Regulation Of Neuron Projection Regeneration Positive Regulation Of Synaptic Transmission, Glutamatergic	Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Flavin-dependent Sulfhydryl Oxidase Activity Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding Thiol Oxidase Activity Shelterin Complex Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere DEAD/H-box RNA Helicase Binding Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Regulation Of DNA Strand Elongation Protein Disulfide Isomerase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Extracellular Matrix Assembly Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding RNA-templated DNA Biosynthetic Process Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening FAD Binding Negative Regulation Of Macroautophagy Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Tertiary Granule Lumen Regulation Of Telomere Maintenance Via Telomere Lengthening Specific Granule Lumen Platelet Alpha Granule Lumen Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomere Maintenance Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance