PML and PPARG

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PML	PPARG
Gene Name		promyelocytic leukemia	peroxisome proliferator-activated receptor gamma
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix PML Body Early Endosome Membrane Nuclear Membrane Extrinsic Component Of Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Cytosol Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding SUMO Binding Protein Homodimerization Activity SMAD Binding Protein Heterodimerization Activity Cobalt Ion Binding	RNA Polymerase II Regulatory Region DNA Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Prostaglandin Receptor Activity Protein Binding Drug Binding Zinc Ion Binding Enzyme Binding Protein Phosphatase Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Retinoid X Receptor Binding Arachidonic Acid Binding Alpha-actinin Binding
	Biological Process	Response To Hypoxia Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Protein Targeting Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Import Into Nucleus Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To UV Response To Gamma Radiation Regulation Of Calcium Ion Transport Into Cytosol Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Negative Regulation Of Cell Growth PML Body Organization Positive Regulation Of Histone Deacetylation Negative Regulation Of Telomere Maintenance Via Telomerase Endoplasmic Reticulum Calcium Ion Homeostasis Circadian Regulation Of Gene Expression Negative Regulation Of Translation In Response To Oxidative Stress Response To Cytokine Regulation Of Circadian Rhythm Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Cell Fate Commitment Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Retinoic Acid Receptor Signaling Pathway Protein Stabilization Maintenance Of Protein Location In Nucleus Defense Response To Virus Negative Regulation Of Telomerase Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Interferon-gamma-mediated Signaling Pathway Branching Involved In Mammary Gland Duct Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-4 Cellular Senescence Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Placenta Development Negative Regulation Of Acute Inflammatory Response Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Heart Development Response To Nutrient Regulation Of Blood Pressure Response To Cold Response To Mechanical Stimulus Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Long-chain Fatty Acid Transport Fatty Acid Oxidation Monocyte Differentiation Negative Regulation Of Cell Growth Epithelial Cell Differentiation Response To Caffeine Organ Regeneration Response To Retinoic Acid Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Response To Lipid Peroxisome Proliferator Activated Receptor Signaling Pathway Response To Immobilization Stress Response To Diuretic Glucose Homeostasis Response To Starvation Regulation Of Circadian Rhythm Lipoprotein Transport Steroid Hormone Mediated Signaling Pathway Response To Estrogen Innate Immune Response Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Cell Maturation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation White Fat Cell Differentiation Brown Fat Cell Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Telomerase Activity Lipid Homeostasis Response To Low-density Lipoprotein Particle Positive Regulation Of Phagocytosis, Engulfment Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Cholesterol Transporter Activity Regulation Of Transcription Involved In Cell Fate Commitment Cellular Response To Lithium Ion Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Prostaglandin E Stimulus Cellular Response To Hyperoxia Response To Metformin Negative Regulation Of Pancreatic Stellate Cell Proliferation
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs			Icosapent Troglitazone Mesalazine Indomethacin Rosiglitazone Nateglinide Sulfasalazine Repaglinide Telmisartan Balsalazide Ibuprofen Glipizide Pioglitazone Mitiglinide Bezafibrate (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID 3-(5-methoxy-1H-indol-3-yl)propanoic acid 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid 2-chloro-5-nitro-N-phenylbenzamide (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid ALEGLITAZAR
Diseases
GWAS		Height ( 20881960) Myopia (pathological) ( 23049088) Paget's disease ( 21623375)	Drug-induced liver injury ( 22968431) Fasting insulin-related traits (interaction with BMI) ( 22581228) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Type 2 diabetes ( 18372903 20581827 17463246 17463248 17463249)
Protein-Protein Interactions		101 interactors: ADH1B ANKRD2 ARID3A ARNT ATF2 ATXN1 AURKA AXIN1 BANP BCL2 BCL6 CASP8AP2 CCNT1 CDK1 CDK2 CDK6 CHFR CREBBP CSNK2A1 DAXX EGFR EIF4E ELF4 EP300 FOS GATA2 HDAC1 HDAC2 HDAC3 HHEX HIPK2 HTT KAT5 KAT6A MAPK11 MAPK14 MDM2 MED7 MXD1 MYB MYC NCOA2 NCOR1 NCOR2 NFKB1 NR3C1 NR4A1 PAWR PAXIP1 PCBD2 PIAS1 PIAS2 PIN1 PLAGL1 PLSCR1 POLR2E PPARG PSMA3 RARA RB1 RBX1 RELA RNF111 RNF125 RNF4 RPL11 RXRA SENP2 SH3GL1 SIAH2 SIN3A SIRT1 SKI SMAD3 SP1 SP100 SRF STAT3 SUMO1 SUMO2 SUMO3 SUV39H1 SYNE2 TDG TERF2IP TGFBR1 TGFBR2 TGIF1 THRA TOPBP1 TP53 TP63 TP73 TRIM24 TRIM27 TRIM69 UBE2I UBE2U UBE3A ZBTB16 ZFYVE9	104 interactors: ALOX15B ANP32A APP BCAS2 BRD8 CDC34 CDK5 CEP350 CHD7 CNOT1 COPS5 CREBBP DNTTIP2 EDF1 EP300 ESR1 ESR2 FABP1 FHOD1 FOXO1 GADD45B GADD45G GRIP1 HDAC1 HDAC3 HDAC4 HELZ2 HMGA1 IKBKB JAZF1 JMJD1C JUN JUND KAT2A KAT5 KCTD13 KIF11 KIF1A LMO4 LRIF1 MAFF MAP2K1 MAPK1 MAPK8 MED1 MED24 MIF4GD MSX2 MUC1 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NFE2L2 NFE2L3 NFKB1 NFKBIB NLK NR0B1 NR0B2 NR2E3 NR4A1 NR4A2 NRIP1 NSD1 PDIA2 PHB2 PML POU1F1 PPARGC1A PPM1B PRKCA RAD54L2 RANBP9 RB1 RELA ROBO4 RXRA RXRB RXRG SERPINH1 SETDB1 SFPQ SMARCD3 STAT6 SVIL SYT1 TFAP2A TNP1 TRIM24 TRIP4 UBC USP7 VDR ZBTB20 ZBTB3 ZBTB5 ZBTB9 ZNF496 ZNHIT3 ZSCAN1
Entrez ID		5371	5468
HPRD ID		00023	03288
Ensembl ID		ENSG00000140464	ENSG00000132170
Uniprot IDs		P29590	D2KUA6 P37231
PDB IDs		1BOR	1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZEO 1ZGY 2ATH 2F4B 2FVJ 2G0G 2G0H 2GTK 2HFP 2HWQ 2HWR 2I4J 2I4P 2I4Z 2OM9 2P4Y 2POB 2PRG 2Q59 2Q5P 2Q5S 2Q61 2Q6R 2Q6S 2Q8S 2QMV 2VSR 2VST 2VV0 2VV1 2VV2 2VV3 2VV4 2XKW 2YFE 2ZK0 2ZK1 2ZK2 2ZK3 2ZK4 2ZK5 2ZK6 2ZNO 2ZVT 3ADS 3ADT 3ADU 3ADV 3ADW 3ADX 3AN3 3AN4 3B0Q 3B0R 3B1M 3B3K 3BC5 3CDP 3CDS 3CS8 3CWD 3D6D 3DZU 3DZY 3E00 3ET0 3ET3 3FEJ 3FUR 3G9E 3GBK 3H0A 3HO0 3HOD 3IA6 3K8S 3KMG 3LMP 3NOA 3OSI 3OSW 3PBA 3PO9 3PRG 3QT0 3R5N 3R8A 3R8I 3S9S 3SZ1 3T03 3TY0 3U9Q 3V9T 3V9V 3V9Y 3VJH 3VJI 3VN2 3VSO 3VSP 4A4V 4A4W 4E4K 4E4Q 4EM9 4EMA 4F9M 4FGY 4HEE 4PRG
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Gene Expression Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Stimulus Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Response To Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Cell Cycle	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway Response To Organic Substance Cellular Metabolic Process Cellular Response To Organic Substance Chromatin Modification Chromatin Organization Response To Hormone Cellular Response To Hormone Stimulus Cellular Response To Lipid Response To Lipid Regulation Of Signaling
Tagcloud ?		anthracycline apl approaches appropriately arsenic corepressors curable cure deacetylase effectiveness explain explains incorporation minority oncogenes pathogenetic plzf progranulocytic promoters ra rar recruit refinement relapsed repression safe timed trioxide vast	abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Difference) ?		anthracycline apl approaches appropriately arsenic corepressors curable cure deacetylase effectiveness explain explains incorporation minority oncogenes pathogenetic plzf progranulocytic promoters ra rar recruit refinement relapsed repression safe timed trioxide vast	abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Intersection) ?