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PPARG
Gene Name
peroxisome proliferator-activated receptor gamma
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Perinuclear Region Of Cytoplasm
RNA Polymerase II Transcription Factor Complex
Molecular Function
RNA Polymerase II Regulatory Region DNA Binding
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Prostaglandin Receptor Activity
Protein Binding
Drug Binding
Zinc Ion Binding
Enzyme Binding
Protein Phosphatase Binding
Estrogen Receptor Binding
Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Activating Transcription Factor Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Retinoid X Receptor Binding
Arachidonic Acid Binding
Alpha-actinin Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Placenta Development
Negative Regulation Of Acute Inflammatory Response
Transcription Initiation From RNA Polymerase II Promoter
Lipid Metabolic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
G-protein Coupled Receptor Signaling Pathway
Heart Development
Response To Nutrient
Regulation Of Blood Pressure
Response To Cold
Response To Mechanical Stimulus
Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Receptor Biosynthetic Process
Negative Regulation Of Cholesterol Storage
Negative Regulation Of Sequestering Of Triglyceride
Long-chain Fatty Acid Transport
Fatty Acid Oxidation
Monocyte Differentiation
Negative Regulation Of Cell Growth
Epithelial Cell Differentiation
Response To Caffeine
Organ Regeneration
Response To Retinoic Acid
Cellular Response To Insulin Stimulus
Negative Regulation Of Collagen Biosynthetic Process
Response To Vitamin A
Response To Lipid
Peroxisome Proliferator Activated Receptor Signaling Pathway
Response To Immobilization Stress
Response To Diuretic
Glucose Homeostasis
Response To Starvation
Regulation Of Circadian Rhythm
Lipoprotein Transport
Steroid Hormone Mediated Signaling Pathway
Response To Estrogen
Innate Immune Response
Cell Fate Commitment
Positive Regulation Of Fat Cell Differentiation
Low-density Lipoprotein Particle Receptor Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Fatty Acid Oxidation
Cell Maturation
Negative Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Oligodendrocyte Differentiation
White Fat Cell Differentiation
Brown Fat Cell Differentiation
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Telomerase Activity
Lipid Homeostasis
Response To Low-density Lipoprotein Particle
Positive Regulation Of Phagocytosis, Engulfment
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Cholesterol Transporter Activity
Regulation Of Transcription Involved In Cell Fate Commitment
Cellular Response To Lithium Ion
Cellular Response To Retinoic Acid
Cellular Response To Vitamin E
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Hyperoxia
Response To Metformin
Negative Regulation Of Pancreatic Stellate Cell Proliferation
Pathways
PPARA activates gene expression
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Icosapent
Troglitazone
Mesalazine
Indomethacin
Rosiglitazone
Nateglinide
Sulfasalazine
Repaglinide
Telmisartan
Balsalazide
Ibuprofen
Glipizide
Pioglitazone
Mitiglinide
Bezafibrate
(S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid
2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
(9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid
2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
(4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid
(5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid
(8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid
(8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid
(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron
(2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
3-(5-methoxy-1H-indol-3-yl)propanoic acid
3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
2-chloro-5-nitro-N-phenylbenzamide
(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
(5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid
3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
(2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid
ALEGLITAZAR
Diseases
GWAS
Drug-induced liver injury (
22968431
)
Fasting insulin-related traits (interaction with BMI) (
22581228
)
Plasminogen activator inhibitor type 1 levels (PAI-1) (
22990020
)
Type 2 diabetes (
18372903
20581827
17463246
17463248
17463249
)
Protein-protein Interactions
104 interactors:
ALOX15B
ANP32A
APP
BCAS2
BRD8
CDC34
CDK5
CEP350
CHD7
CNOT1
COPS5
CREBBP
DNTTIP2
EDF1
EP300
ESR1
ESR2
FABP1
FHOD1
FOXO1
GADD45B
GADD45G
GRIP1
HDAC1
HDAC3
HDAC4
HELZ2
HMGA1
IKBKB
JAZF1
JMJD1C
JUN
JUND
KAT2A
KAT5
KCTD13
KIF11
KIF1A
LMO4
LRIF1
MAFF
MAP2K1
MAPK1
MAPK8
MED1
MED24
MIF4GD
MSX2
MUC1
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NFE2L2
NFE2L3
NFKB1
NFKBIB
NLK
NR0B1
NR0B2
NR2E3
NR4A1
NR4A2
NRIP1
NSD1
PDIA2
PHB2
PML
POU1F1
PPARGC1A
PPM1B
PRKCA
RAD54L2
RANBP9
RB1
RELA
ROBO4
RXRA
RXRB
RXRG
SERPINH1
SETDB1
SFPQ
SMARCD3
STAT6
SVIL
SYT1
TFAP2A
TNP1
TRIM24
TRIP4
UBC
USP7
VDR
ZBTB20
ZBTB3
ZBTB5
ZBTB9
ZNF496
ZNHIT3
ZSCAN1
Entrez ID
5468
HPRD ID
03288
Ensembl ID
ENSG00000132170
Uniprot IDs
D2KUA6
P37231
PDB IDs
1FM6
1FM9
1I7I
1K74
1KNU
1NYX
1PRG
1RDT
1WM0
1ZEO
1ZGY
2ATH
2F4B
2FVJ
2G0G
2G0H
2GTK
2HFP
2HWQ
2HWR
2I4J
2I4P
2I4Z
2OM9
2P4Y
2POB
2PRG
2Q59
2Q5P
2Q5S
2Q61
2Q6R
2Q6S
2Q8S
2QMV
2VSR
2VST
2VV0
2VV1
2VV2
2VV3
2VV4
2XKW
2YFE
2ZK0
2ZK1
2ZK2
2ZK3
2ZK4
2ZK5
2ZK6
2ZNO
2ZVT
3ADS
3ADT
3ADU
3ADV
3ADW
3ADX
3AN3
3AN4
3B0Q
3B0R
3B1M
3B3K
3BC5
3CDP
3CDS
3CS8
3CWD
3D6D
3DZU
3DZY
3E00
3ET0
3ET3
3FEJ
3FUR
3G9E
3GBK
3H0A
3HO0
3HOD
3IA6
3K8S
3KMG
3LMP
3NOA
3OSI
3OSW
3PBA
3PO9
3PRG
3QT0
3R5N
3R8A
3R8I
3S9S
3SZ1
3T03
3TY0
3U9Q
3V9T
3V9V
3V9Y
3VJH
3VJI
3VN2
3VSO
3VSP
4A4V
4A4W
4E4K
4E4Q
4EM9
4EMA
4F9M
4FGY
4HEE
4PRG
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Gene Expression
RNA Metabolic Process
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Intracellular Receptor Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Process
Transcription Initiation From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Intracellular Steroid Hormone Receptor Signaling Pathway
Response To Organic Substance
Cellular Metabolic Process
Cellular Response To Organic Substance
Chromatin Modification
Chromatin Organization
Response To Hormone
Cellular Response To Hormone Stimulus
Cellular Response To Lipid
Response To Lipid
Regulation Of Signaling
Tagcloud
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