RND3 and SKP2

Number of citations of the paper that reports this interaction (PMID 24045951)
0

Data Source:
BioGRID (enzymatic study)

		RND3	SKP2
Gene Name		Rho family GTPase 3	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Focal Adhesion Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Aggresome SCF Ubiquitin Ligase Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding
	Biological Process	Cell Adhesion Small GTPase Mediated Signal Transduction Metabolic Process Actin Cytoskeleton Organization	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion
Pathways			APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation G1 Phase S Phase Cyclin E associated events during G1/S transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 G1/S Transition Regulation of mitotic cell cycle Class I MHC mediated antigen processing & presentation Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases Adaptive Immune System
Drugs
Diseases
GWAS		Endometriosis ( 23472165) Type 2 diabetes ( 22238593)
Protein-Protein Interactions		7 interactors: ARHGAP5 CIT PLXNB1 ROCK1 SKP2 UBC UBXN11	54 interactors: AKT1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MYB MYBL2 MYC NLK ORC1 PFDN1 PIM1 PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1
Entrez ID		390	6502
HPRD ID		04233	03256
Ensembl ID		ENSG00000115963	ENSG00000145604
Uniprot IDs		B2R838 P61587	Q13309
PDB IDs		1M7B 2V55 4BG6	1FQV 1FS1 1FS2 1LDK 2ASS 2AST
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Macromolecule Catabolic Process Intracellular Signal Transduction Rho Protein Signal Transduction Regulation Of Cytoskeleton Organization Proteolysis Cellular Response To Cell-matrix Adhesion Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Catabolic Process Mitotic Cell Cycle Protein Polyubiquitination Cell Communication Neuron Projection Development Membrane To Membrane Docking Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Apical Constriction Ras Protein Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Neuron Development Positive Regulation Of Rho GTPase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Dendrite Morphogenesis Cellular Response To Stimulus Cell Cycle Process Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Bleb Assembly Cellular Protein Metabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Viral Protein Processing Neuron Differentiation Cell Projection Organization Negative Regulation Of Osteoblast Proliferation Myoblast Migration Regulation Of Cellular Component Size	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cell Proliferation DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity DNA Metabolic Process Cellular Protein Modification Process
Tagcloud ?		128a adjacent b1 bioinformatics blotting cdk4 dual expressions fresh hcc hepatocellular luciferase microrna mimics mir mtt nineteen pairs promoted promotes qrt reporter software targeting tissues transfected transfection utr viability	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Difference) ?		128a adjacent b1 bioinformatics blotting cdk4 dual expressions fresh hcc hepatocellular luciferase microrna mimics mir mtt nineteen pairs promoted promotes qrt reporter software targeting tissues transfected transfection utr viability	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Intersection) ?