RND3

Description		Rho family GTPase 3
Image
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		RND3 GTPase cycle
Drugs		Guanosine-5'-Triphosphate
Diseases
GWAS		Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Daytime nap ( 33568662) Endometriosis ( 23472165) Esophageal adenocarcinoma x gastroesophageal reflux disease interaction ( 29551738) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Platelet count ( 31217584) Reticulocyte fraction of red cells ( 32888494) Type 2 diabetes ( 22238593) Urinary metabolite levels in chronic kidney disease ( 29545352)
Novel Interacting Genes		2 novel interacting genes: CDH5 GCH1
Interacting Genes		9 interacting genes: ARHGAP5 C14orf119 CFTR CIT CPLANE2 PLXNB1 ROCK1 SKP2 UBXN11
Entrez ID		390
HPRD ID		04233
Ensembl ID		ENSG00000115963
Uniprot IDs		B2R838 P61587
PDB IDs		1M7B 2V55 4BG6 7OBC 7OBD 8B2K 8BFC
Enriched GO Terms of Interacting Partners?		Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Communication Regulation Of Signaling Epithelial Cell Migration Regulation Of Endothelial Cell Differentiation Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Organelle Organization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding GTP Cyclohydrolase I Activity Rho Protein Signal Transduction Mitotic Cytokinesis GTPase Activity Regulation Of Signal Transduction Positive Regulation Of Anion Channel Activity PDZ Domain Binding Rho-dependent Protein Serine/threonine Kinase Activity Cell Migration Cell Adhesion Membrane Docking Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Nitric-oxide Synthase Activity Cytoskeleton-dependent Cytokinesis Regulation Of Cell Motility Ameboidal-type Cell Migration Regulation Of Locomotion Regulation Of Biological Quality Cell Motility Regulation Of Cell Migration Positive Regulation Of Establishment Of Endothelial Barrier Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Blood Vessel Maturation Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Fibrinogen Binding Regulation Of Epithelial Cell Differentiation Nucleotide Binding Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization
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