TMEM52B and INSIG2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TMEM52B	INSIG2
Name		transmembrane protein 52B	insulin induced gene 2
Structure		No pdb structure
GO Annotations	Cellular Component	Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane SREBP-SCAP-Insig Complex
	Molecular Function	Protein Binding	Protein Binding Oxysterol Binding Lipid Binding Protein Sequestering Activity
	Biological Process	None	NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Biosynthetic Process Response To Sterol Depletion Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Response To Insulin Cellular Response To Insulin Stimulus SREBP Signaling Pathway Response To Lipid SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process Protein Maturation Roof Of Mouth Development Cranial Suture Morphogenesis Response To Fatty Acid
Pathways		None	Regulation of cholesterol biosynthesis by SREBP (SREBF)
GWAS		No GWAS studies recorded	Apolipoprotein B levels ( 32203549 ) Cholesterol, total ( 24097068 ) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809 ) Heel bone mineral density ( 30598549 28869591 ) LDL cholesterol ( 30275531 24097068 ) LDL cholesterol levels ( 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Low density lipoprotein cholesterol levels ( 32154731 33339817 ) Lumbar spine bone mineral density ( 22504420 ) Monobrow ( 27182965 ) Mosquito bite size ( 28199695 ) Total cholesterol levels ( 30275531 )
Interacting Genes		70 interacting genes: ALG3 APOD APOL2 APOL3 BET1 BTN2A2 C1GALT1 C3orf52 CLDN19 CLDN4 CNIH1 CNIH3 CRYAA CSGALNACT2 DNAJC30 EMD FXYD3 GAST GPR25 GPR37L1 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LTC4S MAL MARCHF2 MIP MS4A13 NINJ2 NRM NSG1 ORMDL1 PEDS1-UBE2V1 PGAP2 PLN PLP1 RTP2 SEC22A SERP1 SLC30A2 SLC30A8 SLC35A4 SLC35B4 SLC38A7 SMIM1 TF TMEM100 TMEM107 TMEM109 TMEM128 TMEM147 TMEM14C TMEM203 TMEM218 TMEM267 TMEM50B TMEM54 TMEM60 TMEM86B TMEM97 TMUB2 TRAM1L1 TRARG1 VAMP3 VAMP5 YIPF6 ZDHHC15	55 interacting genes: ABHD4 AQP2 AQP6 ARL13B ATP6V0B BIK CD40 CD79A CPLX4 CREB3L1 CYBC1 EBP ELOVL4 ERGIC3 FAM209A FAM210B GJA8 GOLM1 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LAPTM5 LHFPL5 LMNA MMGT1 MTIF3 MUC1 NEMP1 PCK1 PRLR PSCA PSMA7 PSMB1 PSMC3 PSMC5 PVR RNF5 SCAP SCN3B SLC10A1 SLC16A10 SLC18A1 SLC35H1 SREBF2 STIM1 TMEM14B TMEM237 TMEM45B TMEM52B TMX2 VCP VMA21
Entrez ID		120939	51141
HPRD ID		08709	16361
Ensembl ID		ENSG00000165685	ENSG00000125629
Uniprot IDs		Q4KMG9	B4DQ23 Q9Y5U4
PDB IDs		Not available	4J82 6M49 7ETW
GO Terms Enriched among Interactors		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Membrane Protein Binding Golgi Membrane Localization Within Membrane Establishment Of Protein Localization To Plasma Membrane Cellular Localization Protein Insertion Into Membrane Establishment Of Protein Localization Zinc:proton Antiporter Activity Nuclear Outer Membrane Protein Localization To Membrane Paracellular Transport Protein Localization To Postsynapse Lipid Binding SNAP Receptor Activity Transmembrane Transport Structural Constituent Of Myelin Sheath Zinc Ion Import Into Organelle Intestinal Epithelial Cell Development Pyrimidine Nucleotide-sugar Transmembrane Transport Vesicle-mediated Transport	Membrane Endoplasmic Reticulum Membrane Proteasome Complex Endoplasmic Reticulum C-8 Sterol Isomerase Activity Positive Regulation Of Cholesterol Biosynthetic Process Cytoplasmic Vesicle Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Proteasome-activating Activity Positive Regulation Of Steroid Biosynthetic Process Protein Binding Renal Water Transport Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process SREBP Signaling Pathway Cellular Response To Sterol Depletion Regulation Of Cholesterol Metabolic Process Response To Sterol Depletion Proteasome Regulatory Particle, Base Subcomplex