ARIH1 and PLD1

Number of citations of the paper that reports this interaction (PMID 10926929)
14

Data Source:
HPRD (two hybrid)

		ARIH1	PLD1
Gene Name		ariadne RBR E3 ubiquitin protein ligase 1	phospholipase D1, phosphatidylcholine-specific
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cytokine-mediated Signaling Pathway	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Defense Response To Gram-positive Bacterium
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CUL1 EIF4E2 NEDD8 PLD1 UBE2D1 UBE2D3 UBE2E2 UBE2L3 UBE2L6 VAV2	26 interactors: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL
Entrez ID		25820	5337
HPRD ID		05730	03855
Ensembl ID		ENSG00000166233	ENSG00000075651
Uniprot IDs		Q9Y4X5	Q13393 Q59EA4
PDB IDs		1WD2 4KBL 4KC9
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Response To Organic Substance ISG15-protein Conjugation Cellular Response To Stimulus Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Proteolysis Response To Organic Substance Positive Regulation Of Protein Ubiquitination Response To Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transferase Activity Cell Surface Receptor Signaling Pathway Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Cellular Protein Modification Process Regulation Of Protein Ubiquitination Response To Growth Factor Defense Response Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Proteasomal Protein Catabolic Process Negative Regulation Of Type I Interferon Production Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Innate Immune Response Regulation Of DNA-templated Transcription In Response To Stress Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Communication Enzyme Linked Receptor Protein Signaling Pathway	Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Cellular Response To Stimulus Regulation Of Body Fluid Levels Blood Coagulation Wound Healing Hemostasis Chemotaxis Cell Migration Platelet Activation Membrane Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Organization Cell Motility Response To Stimulus Response To Wounding Regulation Of Vesicle-mediated Transport Regulation Of Cellular Localization Actin Cytoskeleton Organization Actin Filament-based Process Vesicle-mediated Transport Cell Projection Organization Regulation Of Signaling Endocytosis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endocytosis Organelle Organization Cell Activation Signaling Cell Communication Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Cell Projection Assembly Anatomical Structure Morphogenesis Response To Stress Axon Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Apoptotic Process Neuron Projection Morphogenesis Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Cell Death
Tagcloud ?		ariadne c3hc4 cadre conjugating denoted e2s e3 e3s explaining fails hect hects hhari highlighting hybrids ibr ligases obligate park2 parkin rbr rbrs ring ring2 thioester ub ubch5 ubch7 ube2l3	1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld2 responsive se secretion tumorigenesis u87 utilize vegf
Tagcloud (Difference) ?		ariadne c3hc4 cadre conjugating denoted e2s e3 e3s explaining fails hect hects hhari highlighting hybrids ibr ligases obligate park2 parkin rbr rbrs ring ring2 thioester ub ubch5 ubch7 ube2l3	1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld2 responsive se secretion tumorigenesis u87 utilize vegf
Tagcloud (Intersection) ?