ZFYVE1 and PRKCH

Data Source: HiPPIP (Novel)

		ZFYVE1	PRKCH
Name		zinc finger FYVE-type containing 1	protein kinase C eta
Structure		No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Mitochondrion Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Lipid Droplet Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Perinuclear Region Of Cytoplasm Extrinsic Component Of Omegasome Membrane Omegasome	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extracellular Exosome
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Translation Regulator Activity Metal Ion Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding
	Biological Process	Cellular Response To Starvation Macroautophagy Host-mediated Activation Of Viral Genome Replication Lipid Droplet Formation	Regulation Of Translation Protein Phosphorylation Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Translation In Response To Stress Cellular Response To Amino Acid Starvation Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Bicellular Tight Junction Assembly
Pathways		None	Effects of PIP2 hydrolysis G alpha (z) signalling events
GWAS		LDL cholesterol levels ( 32203549 ) Metabolite levels ( 23823483 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665 )	Asthma ( 32296059 ) Height ( 28552196 ) Obesity (early onset extreme) ( 23563609 ) Reading and spelling ( 23738518 ) Rheumatoid arthritis ( 22446963 24390342 30423114 ) Word reading ( 23738518 ) Yeast infection ( 28928442 )
Novel Interactors		2 novel interactors: FGFR1 PRKCH	5 novel interactors: BMP4 C14orf39 SIX6 ZFP36L1 ZFYVE1
Interacting Genes		3 interacting genes: APP BCL2L1 MAGOHB	12 interacting genes: BANP CDK2 FYN GSK3A ITGB2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SRC ZBTB8OS
Entrez ID		53349	5583
HPRD ID		12017	05669
Ensembl ID		ENSG00000165861	ENSG00000027075
Uniprot IDs		Q9HBF4	P24723
PDB IDs		Not available	2FK9 3TXO 8FP1 8FP3
GO Terms Enriched among Interactors		Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Serine/threonine Kinase Binding Regulation Of Cell Junction Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Apoptotic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Apoptotic Process In Bone Marrow Cell Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Synapse Assembly Regulation Of Growth Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Protein Metabolic Process Developmental Maturation Regulation Of Chemotaxis Axon Midline Choice Point Recognition Intracellular Signaling Cassette Positive Regulation Of Chemotaxis Regulation Of Cell Population Proliferation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Differentiation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Postsynapse Organization Cell Development Negative Regulation Of Biosynthetic Process	Regulation Of Cellular Localization Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Establishment Of Protein Localization Response To Growth Factor Forebrain Development Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization To Nucleus Integrin-mediated Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Response To Peptide Hormone Positive Regulation Of Establishment Of Protein Localization T Cell Costimulation Regulation Of Protein Localization To Nucleus Cellular Response To Hormone Stimulus Ephrin Receptor Signaling Pathway Negative Regulation Of Neutrophil Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Development Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Phospholipase Activator Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptide Hormone Receptor Binding Regulation Of Neutrophil Activation Positive Regulation Of Protein Localization BMP Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neutrophil Activation Involved In Immune Response Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Adhesion Regulation Of Striated Muscle Cell Differentiation Protein Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Intracellular Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Chemical Stress Negative Regulation Of Cell Cycle Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Differentiation Regulation Of Developmental Process Leukocyte Activation Tau-protein Kinase Activity Stimulatory C-type Lectin Receptor Signaling Pathway