SLC37A1 and GPR35

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SLC37A1	GPR35
Description		solute carrier family 37 member 1	G protein-coupled receptor 35
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Organelle Membrane	Plasma Membrane Membrane
	Molecular Function	Antiporter Activity Transmembrane Transporter Activity Glucose 6-phosphate:phosphate Antiporter Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity
	Biological Process	Glucose-6-phosphate Transport Phosphate Ion Transmembrane Transport Transmembrane Transport	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Gluconeogenesis	Class A/1 (Rhodopsin-like receptors)
Drugs			Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS			Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		5 interacting genes: ADRB2 GPR35 GPR37 HTR2B SHBG	58 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1
Entrez ID		54020	2859
HPRD ID		10479	16003
Ensembl ID		ENSG00000160190	ENSG00000178623
Uniprot IDs		P57057	A8K2J1 B2RA17 Q9HC97
PDB IDs			8H8J
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of MAPK Cascade Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Blood Vessel Diameter Maintenance Beta-adrenergic Receptor Activity Norepinephrine Binding Regulation Of Tube Size Positive Regulation Of Lipophagy Regulation Of MAPK Cascade AMPA Selective Glutamate Receptor Signaling Pathway Beta2-adrenergic Receptor Activity Prosaposin Receptor Activity Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Androgen Binding Muscle Contraction Receptor Complex Positive Regulation Of Dopamine Metabolic Process Positive Regulation Of Autophagosome Maturation Heat Generation Locomotion Involved In Locomotory Behavior Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Muscle System Process Adrenergic Receptor Activity Dopamine Biosynthetic Process Diet Induced Thermogenesis Vascular Process In Circulatory System Serotonin Binding Serotonin Receptor Signaling Pathway Positive Regulation Of Phospholipid Biosynthetic Process Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Serotonin Receptor Activity Neural Crest Cell Differentiation Negative Regulation Of Multicellular Organism Growth G Protein-coupled Serotonin Receptor Activity Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Circulatory System Process	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Membrane Inorganic Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transport Monoatomic Ion Transport Membrane Organization Cholesterol Metabolic Process Metal Ion Transport Sterol Metabolic Process Inorganic Cation Transmembrane Transport Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transmembrane Transport Import Across Plasma Membrane Sterol Biosynthetic Process Positive Regulation Of Protein Localization Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Cytoplasmic Vesicle Membrane Plasma Membrane Lysosome Glucose 6-phosphate:phosphate Antiporter Activity C-4 Methylsterol Oxidase Activity Lysosomal Membrane Import Into Cell Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Vesicle-mediated Transport Recycling Endosome Glucose-6-phosphate Transport Phagocytic Cup Carbohydrate Derivative Transport Steroid Metabolic Process Potassium Ion Transmembrane Transport Endoplasmic Reticulum Tubular Network Formation Late Endosome Membrane Monoatomic Cation Homeostasis Regulation Of Protein Localization Steroid Biosynthetic Process Monoatomic Ion Homeostasis Postsynaptic Density Proton Transmembrane Transport Cholesterol Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
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