TM6SF2 and SCN3B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TM6SF2	SCN3B
Description		transmembrane 6 superfamily member 2	sodium voltage-gated channel beta subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Voltage-gated Sodium Channel Complex Cytosol Plasma Membrane Membrane Z Disc Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding Identical Protein Binding	Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Lipid Metabolic Process Regulation Of Lipid Metabolic Process Lipid Homeostasis	Monoatomic Ion Transport Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction
Pathways			Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases			Brugada syndrome (BRS)
GWAS		Alanine aminotransferase levels ( 34315874 33547301 33339817) Alcohol-related hepatocellular carcinoma ( 34902334) Aspartate aminotransferase levels ( 34315874 33547301) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cirrhosis (alcohol related) ( 26482880) Cirrhosis (multi-trait analysis) ( 33310085) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Liver enzyme levels (alanine transaminase) ( 33972514) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Medication use (HMG CoA reductase inhibitors) ( 31015401) Nonalcoholic fatty liver disease ( 34841290 24531328 29385134) Nonalcoholic steatohepatitis ( 32298765) Percent liver fat ( 34128465) Schizophrenia ( 23974872 25056061 29483656) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748) Triglyceride levels ( 33339817 29403010 32203549 32154731) Type 2 diabetes ( 29632382 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitamin levels ( 23696881) Waist-to-hip ratio adjusted for BMI ( 34021172)	Chronic lymphocytic leukemia ( 23770605 24292274 28165464) Response to citalopram or escitalopram in depression ( 27622933)
Interacting Genes		10 interacting genes: ARL13B BCL2L13 FAM209A HIBADH KCNJ6 MUC1 PVR SCN3B SSMEM1 TMEM237	116 interacting genes: ADIPOQ AGPAT4 AGPAT5 ANKRD46 AQP10 ARLN ARV1 ATP13A1 ATP6V0C BNIP1 BNIP3 BRICD5 CCDC167 CDIPT CLCA4 CMTM5 CTXN3 CYP4F2 DEFB103A DEFB103B DERL1 DGAT2L6 FAM241B FAM3C FIS1 FKBP8 FXYD3 FXYD6 GIMAP1 GIMAP5 GPR151 GPR61 IER3IP1 INSIG2 ISM2 ITGAM LEMD1 LEPROTL1 LHFPL5 LPAR3 MAL2 MARCHF2 MGST3 MS4A13 NFASC NINJ2 NRM ORMDL1 ORMDL2 PLBD2 PLP2 PLPPR2 PMP22 PNLIPRP1 RHD RNF8 RTP2 RUSF1 SACM1L SCD SEC22A SERP2 SFT2D1 SFXN1 SFXN3 SLC2A5 SLC30A3 SLC30A8 SLC35A4 SLC35E4 SLC38A1 SLC38A7 SLC61A1 SLC7A1 SMCO4 SMIM1 STRIT1 STX3 STX6 STX8 THSD7A TIMM23 TM6SF2 TMBIM6 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM203 TMEM208 TMEM239 TMEM243 TMEM42 TMEM50B TMEM60 TMEM65 TMEM86A TMPPE TPRG1 TRARG1 TSPAN2 TVP23B UBIAD1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAPA VAPB YIF1A YIPF4 YIPF6 ZFPL1
Entrez ID		53345	55800
HPRD ID		12109	10497
Ensembl ID		ENSG00000213996	ENSG00000166257
Uniprot IDs		Q9BZW4	Q9NY72
PDB IDs			4L1D 7TJ8 7TJ9
Enriched GO Terms of Interacting Partners?			Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Protein Binding Membrane Fusion Organelle Fusion Organelle Membrane Fusion Golgi Vesicle Transport Vesicle-mediated Transport Endomembrane System Vesicle Fusion SNARE Complex Assembly Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Intracellular Transport Vesicle Organization Establishment Of Localization In Cell Organelle Localization By Membrane Tethering Transmembrane Transport Golgi Membrane Membrane Docking Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Endoplasmic Reticulum Organization Monoatomic Ion Transmembrane Transporter Activity CDP-diacylglycerol Metabolic Process Mitochondrial Outer Membrane Lipid Metabolic Process Synaptic Vesicle To Endosome Fusion FFAT Motif Binding Serine Import Into Mitochondrion Chemical Homeostasis Mitochondrial Membrane Lipid Biosynthetic Process Amino Acid Transmembrane Transport Neutral Amino Acid Transport Synaptic Vesicle Membrane Protein Transport Syntaxin Binding Establishment Of Protein Localization Monoatomic Ion Transport COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Myelination Axon Ensheathment Establishment Of Protein Localization To Plasma Membrane
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