TM6SF2

Description		transmembrane 6 superfamily member 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Identical Protein Binding
	Biological Process	Lipid Metabolic Process Regulation Of Lipid Metabolic Process Lipid Homeostasis
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301 33339817) Alcohol-related hepatocellular carcinoma ( 34902334) Aspartate aminotransferase levels ( 34315874 33547301) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cirrhosis (alcohol related) ( 26482880) Cirrhosis (multi-trait analysis) ( 33310085) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Liver enzyme levels (alanine transaminase) ( 33972514) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Medication use (HMG CoA reductase inhibitors) ( 31015401) Nonalcoholic fatty liver disease ( 34841290 24531328 29385134) Nonalcoholic steatohepatitis ( 32298765) Percent liver fat ( 34128465) Schizophrenia ( 23974872 25056061 29483656) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748) Triglyceride levels ( 33339817 29403010 32203549 32154731) Type 2 diabetes ( 29632382 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitamin levels ( 23696881) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: ARL13B BCL2L13 FAM209A HIBADH KCNJ6 MUC1 PVR SCN3B SSMEM1 TMEM237
Entrez ID		53345
HPRD ID		12109
Ensembl ID		ENSG00000213996
Uniprot IDs		Q9BZW4
PDB IDs
Enriched GO Terms of Interacting Partners?
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