NUDT9 and EPHA2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NUDT9	EPHA2
Gene Name		nudix (nucleoside diphosphate linked moiety X)-type motif 9	EPH receptor A2
Image
Gene Ontology Annotations	Cellular Component	Intracellular Mitochondrial Matrix Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane
	Molecular Function	ADP-sugar Diphosphatase Activity Adenosine-diphosphatase Activity ADP-ribose Diphosphatase Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Nucleobase-containing Small Molecule Catabolic Process Small Molecule Metabolic Process ADP Catabolic Process IDP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process	Skeletal System Development Angiogenesis Vasculogenesis Osteoblast Differentiation Cell Adhesion Multicellular Organismal Development Axon Guidance Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Viral Process Cell Migration Peptidyl-tyrosine Phosphorylation Neural Tube Development Keratinocyte Differentiation Osteoclast Differentiation Activation Of Rac GTPase Activity Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Post-anal Tail Morphogenesis Protein Kinase B Signaling Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Negative Regulation Of Protein Kinase B Signaling Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways			EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs		Beta-D-Glucose [(2r,3s,4s,5r)-3,4,5-Trihydroxytetrahydrofuran-2-Yl]Methyl Dihydrogen Phosphate	Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib
Diseases
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		3 interactors: APP EPHA2 GLOD4	30 interactors: ACP1 ADRBK1 APP CBL CDH5 CDK17 CLDN4 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR GATAD1 GRB2 KPNA3 LSM7 NUDT9 PIK3R1 PIK3R2 PSME2 PTK2 PTPN11 RASA1 RBL1 SHC1 SLA TIAM1 TNFAIP1 UBE4A
Entrez ID		53343	1969
HPRD ID		09353	01494
Ensembl ID		ENSG00000170502	ENSG00000142627
Uniprot IDs		Q8NG26 Q96KB3 Q9BW91	P29317
PDB IDs		1Q33 1QVJ	1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ
Enriched GO Terms of Interacting Partners?		Notochord Cell Development Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Axial Mesoderm Formation Axon Guidance Collateral Sprouting Axon Midline Choice Point Recognition Notochord Formation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lens Fiber Cell Morphogenesis Axial Mesoderm Morphogenesis Axonogenesis Axon Choice Point Recognition Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Remodeling Axial Mesoderm Development Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Notochord Morphogenesis Activation Of Rac GTPase Activity Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cellular Copper Ion Homeostasis Lens Fiber Cell Development Neuron Development Apoptotic Process Post-anal Tail Morphogenesis Mammary Gland Epithelial Cell Proliferation Notochord Development Copper Ion Homeostasis Suckling Behavior Programmed Cell Death Positive Regulation Of Hydrolase Activity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Lamellipodium Assembly Cell Death Death Cell Morphogenesis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Plasma Membrane Neuron Differentiation Lens Morphogenesis In Camera-type Eye Cell Projection Organization Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Adhesion	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Locomotion Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Chemotaxis Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Growth Factor Neuron Projection Development Cell Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis Neurotrophin Signaling Pathway Neuron Development Cell Morphogenesis Signal Transduction Regulation Of Signal Transduction Neuron Differentiation Cell Projection Organization Signaling Regulation Of Signaling Cell Communication Fc Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Migration Regulation Of ERBB Signaling Pathway Cell Motility Generation Of Neurons Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Catalytic Activity Neurogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Regulation Of Body Fluid Levels
Tagcloud ?		absent adp adpr ca2 cation channel characterised cnidarian decipher distant enabled faster gating h2o2 hardly htrpm2 mediator modulatory nematostella nvtrpm2 orthologue pronounced pyrophosphatase resemblance ribose shed stretch trpm2 vectensis	abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip
Tagcloud (Difference) ?		absent adp adpr ca2 cation channel characterised cnidarian decipher distant enabled faster gating h2o2 hardly htrpm2 mediator modulatory nematostella nvtrpm2 orthologue pronounced pyrophosphatase resemblance ribose shed stretch trpm2 vectensis	abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip
Tagcloud (Intersection) ?