TRAF7 and HDGF

		TRAF7	HDGF
Description		TNF receptor associated factor 7	heparin binding growth factor
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Plasma Membrane Cytoplasmic Vesicle	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Binding Actin Binding Protein Binding Growth Factor Activity Heparin Binding Tubulin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein K29-linked Ubiquitination Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Signal Transduction Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	XBP1(S) activates chaperone genes
Drugs			Copper
Diseases
GWAS		Diastolic blood pressure ( 30578418) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Blood protein levels ( 30072576) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: CYLD MAP3K3 OGT RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6	7 interacting genes: APP CEBPA EIF4ENIF1 GPR37 JUN SMAD4 XBP1
Entrez ID		84231	3068
HPRD ID		06977	02079
Ensembl ID		ENSG00000131653	ENSG00000143321
Uniprot IDs		B3KQY7 Q6Q0C0	A0A384NPW1 A8K8G0 B7Z958 P51858
PDB IDs		8IMS	1RI0 2NLU
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Nucleotide Binding Ubiquitin-ubiquitin Ligase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Ubiquitination Ubiquitin-like Protein Transferase Activity ATP Binding Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Regulation Of Necroptotic Process Positive Regulation Of Protein Modification Process Regulation Of Programmed Necrotic Cell Death Protein-containing Complex Regulation Of DNA-binding Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of P38MAPK Cascade Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Positive Regulation Of Protein Metabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Gene Expression Involved In Extracellular Matrix Organization Cytosol Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction TORC1 Signaling Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Autoubiquitination	Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade RNA Polymerase II Transcription Regulator Complex Intracellular Signaling Cassette Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Gland Development Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Liver Development Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Signal Transduction Interleukin-6-mediated Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signaling Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of RNA Metabolic Process Cell Maturation Neuron Projection Development Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Metal Ion Epithelial Cell Maturation SMAD Protein Signal Transduction Ubiquitin-like Protein Ligase Binding R-SMAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Microglial Cell Activation Carbohydrate Homeostasis Glucose Homeostasis Developmental Maturation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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