PKP1 and GTF2IRD1

Number of citations of the paper that reports this interaction (PubMedID 26275350)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PKP1	GTF2IRD1
Description		plakophilin 1	GTF2I repeat domain containing 1
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GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Adherens Junction Cytoplasmic Stress Granule Membrane Desmosome Perinuclear Region Of Cytoplasm Anchoring Junction Nuclear Stress Granule Ficolin-1-rich Granule Membrane	Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Skin Epidermis Cadherin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Desmosome Assembly Desmosome Maintenance Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Transepithelial Water Transport Ameloblast Differentiation Intermediate Filament Bundle Assembly Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Protein Localization To Membrane	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transition Between Slow And Fast Fiber
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases		Ectodermal dysplasia/skin fragility syndrome
GWAS		Panic disorder ( 19165232) Youthful appearance (self-reported) ( 32339537)	Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Rheumatoid arthritis ( 32723749) Severe influenza A (H1N1) infection ( 26379185) Sjögren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469) Triglyceride levels ( 32203549)
Interacting Genes		17 interacting genes: ARMC8 BICDL2 CARD10 CEP76 DSC1 DSG1 DSP GOLGA2 GTF2IRD1 HOOK2 HSF2BP KRT14 KRT8 NFKBID TNS2 UCHL5 VIM	24 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5
Entrez ID		5317	9569
HPRD ID		03579	08379
Ensembl ID		ENSG00000081277	ENSG00000006704
Uniprot IDs		Q13835	E9PFE2 Q9UHL9
PDB IDs		1XM9	2D99 2DN5 2DZQ 2DZR
Enriched GO Terms of Interacting Partners?		Cornified Envelope Desmosome Intermediate Filament Keratin Filament Binding Ficolin-1-rich Granule Membrane Intermediate Filament Organization Scaffold Protein Binding Desmosome Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Cytoskeleton Epidermis Development Anchoring Junction Cell-cell Junction Organization	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Import Into Nucleus Import Into Nucleus Intermediate Filament Binding Intracellular Transport Of Virus Intermediate Filament Bundle Assembly Desmosome Assembly Nucleoplasm Host Cell Protein Localization To Nucleus SUMO Ligase Activity Positive Regulation Of Protein Localization To Cell Periphery Desmosome Organization Nuclear Pore Ubiquitin-specific Protease Binding Positive Regulation Of Protein Localization SUMO Transferase Activity Nuclear Transport Nucleocytoplasmic Transport SMAD Protein Signal Transduction Desmosome Ubiquitin Protein Ligase Binding Intracellular Protein Transport Cellular Localization Collagen Type XV Trimer Establishment Of Protein Localization To Organelle Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Cell Periphery Maintenance Of Protein Localization At Cell Tip Positive Regulation Of Ferroptosis
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