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PKP1
Description
plakophilin 1
Image
GO Annotations
Cellular Component
Cornified Envelope
Nucleus
Nucleoplasm
Cytoplasm
Intermediate Filament
Plasma Membrane
Adherens Junction
Cytoplasmic Stress Granule
Membrane
Desmosome
Perinuclear Region Of Cytoplasm
Anchoring Junction
Nuclear Stress Granule
Ficolin-1-rich Granule Membrane
Molecular Function
DNA Binding
RNA Binding
Protein Binding
Lamin Binding
Intermediate Filament Binding
Structural Constituent Of Skin Epidermis
Cadherin Binding
Biological Process
Desmosome Assembly
Desmosome Maintenance
Cell Adhesion
Signal Transduction
Positive Regulation Of Gene Expression
Positive Regulation Of Cell-cell Adhesion
Transepithelial Water Transport
Ameloblast Differentiation
Intermediate Filament Bundle Assembly
Positive Regulation Of Keratinocyte Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cell-cell Adhesion
Negative Regulation Of MRNA Catabolic Process
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cap-dependent Translational Initiation
Positive Regulation Of Protein Localization To Membrane
Pathways
Apoptotic cleavage of cell adhesion proteins
Neutrophil degranulation
Keratinization
Formation of the cornified envelope
Drugs
Diseases
Ectodermal dysplasia/skin fragility syndrome
GWAS
Panic disorder (
19165232
)
Youthful appearance (self-reported) (
32339537
)
Novel Interacting Genes
1 novel interacting genes:
AP2B1
Interacting Genes
17 interacting genes:
ARMC8
BICDL2
CARD10
CEP76
DSC1
DSG1
DSP
GOLGA2
GTF2IRD1
HOOK2
HSF2BP
KRT14
KRT8
NFKBID
TNS2
UCHL5
VIM
Entrez ID
5317
HPRD ID
03579
Ensembl ID
ENSG00000081277
Uniprot IDs
Q13835
PDB IDs
1XM9
Enriched GO Terms of Interacting Partners
?
Cornified Envelope
Desmosome
Intermediate Filament
Keratin Filament Binding
Ficolin-1-rich Granule Membrane
Intermediate Filament Organization
Scaffold Protein Binding
Desmosome Organization
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Structural Constituent Of Cytoskeleton
Epidermis Development
Anchoring Junction
Cell-cell Junction Organization
Tagcloud
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