PKP1 and KRT8

Number of citations of the paper that reports this interaction (PubMedID 10852826)
0

Data Source:
HPRD (in vitro)

		PKP1	KRT8
Description		plakophilin 1	keratin 8
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Adherens Junction Cytoplasmic Stress Granule Membrane Desmosome Perinuclear Region Of Cytoplasm Anchoring Junction Nuclear Stress Granule Ficolin-1-rich Granule Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cell-cell Junction Apicolateral Plasma Membrane Nuclear Matrix Z Disc Sarcolemma Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome Cell Periphery
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Skin Epidermis Cadherin Binding	Protein Binding Scaffold Protein Binding
	Biological Process	Desmosome Assembly Desmosome Maintenance Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Transepithelial Water Transport Ameloblast Differentiation Intermediate Filament Bundle Assembly Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Protein Localization To Membrane	Tumor Necrosis Factor-mediated Signaling Pathway Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs			Tenecteplase Lanoteplase Copper
Diseases		Ectodermal dysplasia/skin fragility syndrome
GWAS		Panic disorder ( 19165232) Youthful appearance (self-reported) ( 32339537)	Alanine aminotransferase levels ( 33339817 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Cancer (pleiotropy) ( 27197191) Gamma glutamyl transferase levels ( 29403010) Mean reticulocyte volume ( 32888494) Opioid dependence (time to event) ( 34124712) Prostate cancer ( 21743057) Sick sinus syndrome ( 33580673)
Interacting Genes		17 interacting genes: ARMC8 BICDL2 CARD10 CEP76 DSC1 DSG1 DSP GOLGA2 GTF2IRD1 HOOK2 HSF2BP KRT14 KRT8 NFKBID TNS2 UCHL5 VIM	53 interacting genes: ANXA1 BYSL CEP57 CLK1 DEDD DMD EGFR ESR1 FBXO25 FGFR3 GRB2 HSPA5 IKBKG KIFC3 KPNA2 KRT13 KRT15 KRT16 KRT18 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT32 KRT33B KRT35 KRT36 KRT37 KRT38 KRT40 LINC01554 MAPK1 MAPK14 MAPK3 MAPK8 NEK6 OGT PIWIL2 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 SUMO2 TCHP TFIP11 TRIM54 TROAP WBP2
Entrez ID		5317	3856
HPRD ID		03579	01015
Ensembl ID		ENSG00000081277	ENSG00000170421
Uniprot IDs		Q13835	P05787 Q7L4M3
PDB IDs		1XM9	7K3C 7K3X 7K3Y
Enriched GO Terms of Interacting Partners?		Cornified Envelope Desmosome Intermediate Filament Keratin Filament Binding Ficolin-1-rich Granule Membrane Intermediate Filament Organization Scaffold Protein Binding Desmosome Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Cytoskeleton Epidermis Development Anchoring Junction Cell-cell Junction Organization	Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Epithelial Cell Differentiation Cytoskeleton Organization Cytoskeleton Supramolecular Fiber Organization Anatomical Structure Morphogenesis Cellular Developmental Process Cell Differentiation Organelle Organization Developmental Process Cytosol Extracellular Exosome MAP Kinase Activity Schwann Cell Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Desmosome ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Response To Mechanical Stimulus Insulin-like Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Hair Cycle Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Tissue Development Structural Constituent Of Cytoskeleton Pseudopodium Protein Kinase Activity Interleukin-34-mediated Signaling Pathway Cornified Envelope Protein Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cyclase Activity Face Development Epidermal Growth Factor Receptor Signaling Pathway Glial Cell Development Regulation Of Golgi Inheritance Response To Muscle Stretch
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