PKP1 and KRT14

Number of citations of the paper that reports this interaction (PMID 10852826)
18

Data Source:
HPRD (in vitro)

		PKP1	KRT14
Gene Name		plakophilin 1	keratin 14, type I
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Intermediate Filament Plasma Membrane Desmosome Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Signal Transducer Activity Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Epidermis	Structural Constituent Of Cytoskeleton Protein Binding Keratin Filament Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Signal Transduction Multicellular Organismal Development Single Organismal Cell-cell Adhesion Intermediate Filament Bundle Assembly	Aging Epidermis Development Response To Zinc Ion Response To Ionizing Radiation Epithelial Cell Differentiation Hemidesmosome Assembly Cell Junction Assembly Hair Cycle Intermediate Filament Bundle Assembly
Pathways		Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase	Cell junction organization Type I hemidesmosome assembly
Drugs
Diseases
GWAS		Panic disorder ( 19165232)
Protein-Protein Interactions		8 interactors: DSC1 DSG1 DSP KRT14 KRT8 TNS2 UCHL5 VIM	10 interactors: APC DST HSPA5 KRT5 PKP1 SUMO1 SUMO2 SUMO3 TCHP TRADD
Entrez ID		5317	3861
HPRD ID		03579	01017
Ensembl ID		ENSG00000081277	ENSG00000186847
Uniprot IDs		Q13835	P02533
PDB IDs		1XM9	3TNU
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Anatomical Structure Development Apoptotic Process Programmed Cell Death Response To Stimulus Cell Death Developmental Process Death Cytoskeleton Organization System Development Epithelial Cell Differentiation Ventricular Compact Myocardium Morphogenesis Multicellular Organismal Development Organ Development Protein Localization To Adherens Junction Intermediate Filament Bundle Assembly Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Junction Organization Response To Hydrostatic Pressure Bergmann Glial Cell Differentiation Bundle Of His Cell To Purkinje Myocyte Communication Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Localization To Cell Junction Signaling Central Nervous System Development Epidermis Development Cell Communication Hemidesmosome Assembly Desmosome Organization Epithelium Development Response To Muscle Activity Cell Adhesion Hepatocyte Apoptotic Process Lens Fiber Cell Development Ventricular Cardiac Muscle Cell Action Potential Forebrain Morphogenesis Astrocyte Development Regulation Of Heart Rate By Cardiac Conduction Lateral Ventricle Development	Protein Sumoylation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Hemidesmosome Assembly Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Cell Junction Assembly Post-translational Protein Modification Regulation Of Protein Metabolic Process Intermediate Filament Cytoskeleton Organization Peptidyl-lysine Modification Intermediate Filament-based Process Cell-substrate Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Execution Phase Of Apoptosis Regulation Of Protein Folding In Endoplasmic Reticulum Apoptotic Process Programmed Cell Death Cellular Component Assembly Cell Death Death Cerebellum Structural Organization Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Protein Localization To Organelle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Cell Cycle Arrest Cellular Response To Cytokine Stimulus PML Body Organization Negative Regulation Of Odontogenesis Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Complex Assembly Protein Localization To Nucleus Positive Regulation Of Cellular Metabolic Process Protein Localization To Nuclear Pore Intermediate Filament Bundle Assembly Response To Cytokine Protein Localization To Nuclear Envelope Metaphase/anaphase Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Regulation Of Protein Ubiquitination
Tagcloud ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside pabpc1 particles pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	amu arising carcinogenic chimera densely distinguished earth elicits esr1 faster grew grow hosts ionizing irradiated k14 k18 keratin krt18 mev oncology radiation sham si sparsely stroma syngeneic tended trp53
Tagcloud (Difference) ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside pabpc1 particles pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	amu arising carcinogenic chimera densely distinguished earth elicits esr1 faster grew grow hosts ionizing irradiated k14 k18 keratin krt18 mev oncology radiation sham si sparsely stroma syngeneic tended trp53
Tagcloud (Intersection) ?