PKD2 and MTAP

		PKD2	MTAP
Description		polycystin 2, transient receptor potential cation channel	methylthioadenosine phosphorylase
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GO Annotations	Cellular Component	Polycystin Complex Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Membrane Basolateral Plasma Membrane Lamellipodium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Motile Cilium Vesicle Monoatomic Ion Channel Complex Cation Channel Complex Ciliary Basal Body Cell Projection Basal Cortex Ciliary Membrane Extracellular Exosome Mitotic Spindle Non-motile Cilium Lumenal Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane Migrasome	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Channel Activity Outward Rectifier Potassium Channel Activity Voltage-gated Monoatomic Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Transmembrane Transporter Binding Metal Ion Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding Transcription Regulator Inhibitor Activity	Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity S-methyl-5-thioadenosine Phosphorylase Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Spinal Cord Development Neural Tube Development Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Population Proliferation Chordate Embryonic Development Cilium Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Protein Tetramerization Protein Homotetramerization Protein Heterotetramerization Centrosome Duplication Establishment Of Localization In Cell Regulation Of Cell Cycle Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Inorganic Cation Transmembrane Transport Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Nicotinamide Riboside Catabolic Process Nucleoside Metabolic Process L-methionine Salvage From Methylthioadenosine Methylation Response To Testosterone
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Adenine (2S,3S,4R,5S)-2-(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-3,4-pyrrolidinediol Formycin 5'-S-methyl-5'-thioadenosine 5'-Deoxy-5'-(Methylthio)-Tubercidin
Diseases		Polycystic kidney disease
GWAS		Coffee consumption (cups per day) ( 25288136) Dental caries ( 23064961) Gout ( 30899057) Hyperuricemia ( 28776340) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels in response to allopurinol in gout ( 25676789) Uric acid levels ( 29558500)	Adverse response to drug ( 30420678) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary heart disease ( 21606135) Cutaneous malignant melanoma ( 32341527) Cutaneous nevi ( 19578365) Diastolic blood pressure ( 28135244) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Glycated hemoglobin levels ( 28898252) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Macular thickness ( 30535121) Mean spheric corpuscular volume ( 32888494) Melanoma ( 28212542 21983787) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480 32341527) Pediatric bone mineral content (radius) ( 26041818) Pulse pressure ( 28135244)
Interacting Genes		21 interacting genes: ACTN2 CD2AP CYSRT1 DIAPH1 HAX1 HSF2BP KRT40 KRTAP10-3 KRTAP10-8 KRTAP6-2 LMNA MAGEA8 MDFI PACS1 PACS2 PKD1 PLSCR1 PTPRG TNNI3 TPM1 TRPC1	7 interacting genes: CDC25A CENPH EMC3 FOLH1 LYRM1 MYLIP RELB
Entrez ID		5311	4507
HPRD ID		01437	01134
Ensembl ID		ENSG00000118762	ENSG00000099810
Uniprot IDs		Q13563 Q9UEU6	A0A384ME80 B4DUC8 Q13126
PDB IDs		2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO 5K47 5MKE 5MKF 5T4D 6A70 6D1W 6T9N 6T9O 6WB8 8HK7 8K3S 9DLI 9DWQ	1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Binding Intermediate Filament Actin Filament Sarcomere Alcohol Dehydrogenase (NAD+) Activity Actin Filament Binding Striated Muscle Cell Development Regulation Of Cytoskeleton Organization Actin Binding Cytosol All-trans-retinol Dehydrogenase (NAD+) Activity Cation Channel Complex Actin-myosin Filament Sliding Muscle Filament Sliding Protein Domain Specific Binding Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Keratin Filament Muscle Cell Development Structural Constituent Of Cytoskeleton Regulation Of Muscle System Process Positive Regulation Of Cation Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Retinoic Acid Metabolic Process Protein Heterooligomerization Actin Cytoskeleton Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Actin Filament Uncapping Identical Protein Binding Butanol Dehydrogenase (NAD+) Activity Ethanol Dehydrogenase (NAD+) Activity Actin Filament Polymerization Regulation Of Calcium Ion Transmembrane Transport Regulation Of System Process S-methyl-5-thioadenosine Phosphorylase Activity Metanephric Distal Tubule Morphogenesis Monoatomic Cation Channel Activity Regulation Of ATP-dependent Activity Negative Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Heart Rate By Epinephrine Actin-mediated Cell Contraction	Intestinal Folate Absorption Tetrahydrofolyl-poly(glutamate) Polymer Binding Ac-Asp-Glu Binding Release Of Sequestered Calcium Ion Into Cytosol Metanephric Cortical Collecting Duct Development Cellular Response To Osmotic Stress Metanephric Cortex Development Metanephric Distal Tubule Development Negative Regulation Of Sequestering Of Calcium Ion G-protein Beta/gamma-subunit Complex Cytoskeletal Protein Binding Response To Osmotic Stress Calcium Ion Transmembrane Import Into Cytosol Polycystin Complex Metanephric Smooth Muscle Tissue Development Renal Artery Morphogenesis Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Metanephric Part Of Ureteric Bud Development Regulation Of Sequestering Of Calcium Ion Migrasome Metanephric Ascending Thin Limb Development Distal Tubule Development Cellular Response To Hydrostatic Pressure HLH Domain Binding Metanephric S-shaped Body Morphogenesis Detection Of Nodal Flow NF-kappaB Complex Calcium-induced Calcium Release Activity Basal Cortex Nephric Duct Development Mesonephric Duct Development Sensory Perception Of Bitter Taste Glutamate Biosynthetic Process S-shaped Body Morphogenesis Determination Of Liver Left/right Asymmetry Response To Hydrostatic Pressure Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Kinetochore Binding Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metanephric Mesenchyme Development Phosphatidylinositol Phospholipase C Activity
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