PKD2 and ADH1A

Data Source: HiPPIP (Novel)

		PKD2	ADH1A
Name		polycystin 2, transient receptor potential cation channel	alcohol dehydrogenase 1A (class I), alpha polypeptide
Structure
GO Annotations	Cellular Component	Polycystin Complex Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Membrane Basolateral Plasma Membrane Lamellipodium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Motile Cilium Vesicle Monoatomic Ion Channel Complex Cation Channel Complex Ciliary Basal Body Cell Projection Basal Cortex Ciliary Membrane Extracellular Exosome Mitotic Spindle Non-motile Cilium Lumenal Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane Migrasome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Ciliary Basal Body
	Molecular Function	Signaling Receptor Binding Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Channel Activity Outward Rectifier Potassium Channel Activity Voltage-gated Monoatomic Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Transmembrane Transporter Binding Metal Ion Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding Transcription Regulator Inhibitor Activity	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding Butanol Dehydrogenase (NAD+) Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Spinal Cord Development Neural Tube Development Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Population Proliferation Chordate Embryonic Development Cilium Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Protein Tetramerization Protein Homotetramerization Protein Heterotetramerization Centrosome Duplication Establishment Of Localization In Cell Regulation Of Cell Cycle Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Inorganic Cation Transmembrane Transport Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Alcohol Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Abacavir metabolism RA biosynthesis pathway Ethanol oxidation
Drugs		None	NADH Fomepizole 4-Iodopyrazole N-Cyclopentyl-N-Cyclobutylformamide
Diseases		Polycystic kidney disease	None
GWAS		Coffee consumption (cups per day) ( 25288136 ) Dental caries ( 23064961 ) Gout ( 30899057 ) Hyperuricemia ( 28776340 ) Serum alkaline phosphatase levels ( 33547301 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 ) Uric acid levels ( 29558500 )	Alcohol consumption (drinks per week) ( 30643258 ) Alcohol dependence ( 23456092 33290381 ) Regular attendance at a pub or social club ( 29970889 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )
Novel Interactors		6 novel interactors: ADH1A ADH1C KIF11 MTAP PPP3CA UCHL3	1 novel interactors: PKD2
Interacting Genes		21 interacting genes: ACTN2 CD2AP CYSRT1 DIAPH1 HAX1 HSF2BP KRT40 KRTAP10-3 KRTAP10-8 KRTAP6-2 LMNA MAGEA8 MDFI PACS1 PACS2 PKD1 PLSCR1 PTPRG TNNI3 TPM1 TRPC1	2 interacting genes: CSNK2A2 HADH
Entrez ID		5311	124
HPRD ID		01437	00063
Ensembl ID		ENSG00000118762	ENSG00000187758
Uniprot IDs		Q13563 Q9UEU6	P07327
PDB IDs		2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO 5K47 5MKE 5MKF 5T4D 6A70 6D1W 6T9N 6T9O 6WB8 8HK7 8K3S 9DLI 9DWQ	1HSO 1U3T
GO Terms Enriched among Interactors		Transmembrane Transporter Binding Intermediate Filament Actin Filament Sarcomere Alcohol Dehydrogenase (NAD+) Activity Actin Filament Binding Striated Muscle Cell Development Regulation Of Cytoskeleton Organization Actin Binding Cytosol All-trans-retinol Dehydrogenase (NAD+) Activity Cation Channel Complex Actin-myosin Filament Sliding Muscle Filament Sliding Protein Domain Specific Binding Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Keratin Filament Muscle Cell Development Structural Constituent Of Cytoskeleton Regulation Of Muscle System Process Positive Regulation Of Cation Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Retinoic Acid Metabolic Process Protein Heterooligomerization Actin Cytoskeleton Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Actin Filament Uncapping Identical Protein Binding Butanol Dehydrogenase (NAD+) Activity Ethanol Dehydrogenase (NAD+) Activity Actin Filament Polymerization Regulation Of Calcium Ion Transmembrane Transport Regulation Of System Process S-methyl-5-thioadenosine Phosphorylase Activity Metanephric Distal Tubule Morphogenesis Monoatomic Cation Channel Activity Regulation Of ATP-dependent Activity Negative Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Heart Rate By Epinephrine Actin-mediated Cell Contraction	Liver Development Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development Wnt Signaling Pathway Protein Kinase CK2 Complex Gland Development Metanephric Part Of Ureteric Bud Development Calcium-induced Calcium Release Activity Migrasome Polycystin Complex Metanephric Smooth Muscle Tissue Development Metanephric Ascending Thin Limb Development Renal Artery Morphogenesis Distal Tubule Development Cellular Response To Hydrostatic Pressure Basal Cortex HLH Domain Binding Nephric Duct Development Mesonephric Duct Development Metanephric S-shaped Body Morphogenesis Detection Of Nodal Flow (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity S-shaped Body Morphogenesis Determination Of Liver Left/right Asymmetry Response To Hydrostatic Pressure Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metanephric Mesenchyme Development Voltage-gated Monoatomic Cation Channel Activity Response To Water Voltage-gated Monoatomic Ion Channel Activity Male Gamete Generation Spermatogenesis Regulation Of Establishment Of Protein Localization Gamete Generation Muscle Alpha-actinin Binding Metanephric Epithelium Development Cytoplasmic Side Of Endoplasmic Reticulum Membrane Cation Channel Complex Voltage-gated Sodium Channel Activity Renal Tubule Morphogenesis Protein Heterotetramerization Metanephric Tubule Development Outward Rectifier Potassium Channel Activity Actinin Binding Metanephric Nephron Tubule Development NAD+ Binding Centrosome Duplication Smooth Muscle Tissue Development Nephron Tubule Development