ADH1A

Gene Name		alcohol dehydrogenase 1A (class I), alpha polypeptide
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Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Alcohol Dehydrogenase (NAD) Activity Alcohol Dehydrogenase Activity, Zinc-dependent Protein Binding Zinc Ion Binding
	Biological Process	Alcohol Metabolic Process Ethanol Oxidation Xenobiotic Metabolic Process Drug Metabolic Process Small Molecule Metabolic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Ethanol oxidation Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations RA biosynthesis pathway Abacavir transport and metabolism Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Signaling by Retinoic Acid Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Abacavir metabolism Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		NADH Ethanol Fomepizole Nicotinamide-Adenine-Dinucleotide 4-Iodopyrazole N-Cyclopentyl-N-Cyclobutylformamide
Diseases
GWAS		Alcohol dependence ( 23456092)
Protein-protein Interactions		2 interactors: CSNK2A2 HADH
Entrez ID		124
HPRD ID		00063
Ensembl ID		ENSG00000187758
Uniprot IDs		P07327
PDB IDs		1HSO 1U3T
Enriched GO Terms of Interacting Partners?		Cardiolipin Acyl-chain Remodeling Cardiolipin Metabolic Process Negative Regulation Of Insulin Secretion Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Negative Regulation Of Peptide Secretion Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Fatty Acid Beta-oxidation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Response To Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hormone Secretion Negative Regulation Of Proteasomal Protein Catabolic Process Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of Protein Secretion
Tagcloud ?		4r a5 alcoholic aldehyde aldh1l1 anxa5 bcl2a1 bcl2l2 cirrhosis gadd45a ifngr2 il2rb il4 myeloperoxidase natriuretic nfkappabeta nfkb nibp nkiras2 nox5 nppa peroxisomal pex5 pparg tank tegt tnfrsf9 traf ttrap