ADH1A

Description		alcohol dehydrogenase 1A (class I), alpha polypeptide
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Ciliary Basal Body
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding Butanol Dehydrogenase (NAD+) Activity
	Biological Process	Alcohol Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		Abacavir metabolism RA biosynthesis pathway Ethanol oxidation
Drugs		NADH Fomepizole 4-Iodopyrazole N-Cyclopentyl-N-Cyclobutylformamide
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Alcohol dependence ( 23456092 33290381) Regular attendance at a pub or social club ( 29970889) Urinary metabolite levels in chronic kidney disease ( 31959995)
Novel Interacting Genes		1 novel interacting genes: PKD2
Interacting Genes		2 interacting genes: CSNK2A2 HADH
Entrez ID		124
HPRD ID		00063
Ensembl ID		ENSG00000187758
Uniprot IDs		P07327
PDB IDs		1HSO 1U3T
Enriched GO Terms of Interacting Partners?		Liver Development Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development Wnt Signaling Pathway Protein Kinase CK2 Complex Gland Development Metanephric Part Of Ureteric Bud Development Calcium-induced Calcium Release Activity Migrasome Polycystin Complex Metanephric Smooth Muscle Tissue Development Metanephric Ascending Thin Limb Development Renal Artery Morphogenesis Distal Tubule Development Cellular Response To Hydrostatic Pressure Basal Cortex HLH Domain Binding Nephric Duct Development Mesonephric Duct Development Metanephric S-shaped Body Morphogenesis Detection Of Nodal Flow (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity S-shaped Body Morphogenesis Determination Of Liver Left/right Asymmetry Response To Hydrostatic Pressure Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metanephric Mesenchyme Development Voltage-gated Monoatomic Cation Channel Activity Response To Water Voltage-gated Monoatomic Ion Channel Activity Male Gamete Generation Spermatogenesis Regulation Of Establishment Of Protein Localization Gamete Generation Muscle Alpha-actinin Binding Metanephric Epithelium Development Cytoplasmic Side Of Endoplasmic Reticulum Membrane Cation Channel Complex Voltage-gated Sodium Channel Activity Renal Tubule Morphogenesis Protein Heterotetramerization Metanephric Tubule Development Outward Rectifier Potassium Channel Activity Actinin Binding Metanephric Nephron Tubule Development NAD+ Binding Centrosome Duplication Smooth Muscle Tissue Development Nephron Tubule Development
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