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ADH1A and HADH
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
ADH1A
HADH
Description
alcohol dehydrogenase 1A (class I), alpha polypeptide
hydroxyacyl-CoA dehydrogenase
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Ciliary Basal Body
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Molecular Function
Alcohol Dehydrogenase (NAD+) Activity
All-trans-retinol Dehydrogenase (NAD+) Activity
Protein Binding
Zinc Ion Binding
Oxidoreductase Activity
Metal Ion Binding
Butanol Dehydrogenase (NAD+) Activity
(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
Oxidoreductase Activity
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Transferase Activity
Identical Protein Binding
NAD+ Binding
Biological Process
Alcohol Metabolic Process
Retinol Metabolic Process
Retinoic Acid Metabolic Process
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Beta-oxidation
Spermatogenesis
Response To Xenobiotic Stimulus
Response To Hormone
Response To Activity
Cell Differentiation
Response To Insulin
Negative Regulation Of Insulin Secretion
Regulation Of Insulin Secretion
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Abacavir metabolism
RA biosynthesis pathway
Ethanol oxidation
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Beta oxidation of butanoyl-CoA to acetyl-CoA
Mitochondrial protein degradation
Drugs
NADH
Fomepizole
4-Iodopyrazole
N-Cyclopentyl-N-Cyclobutylformamide
NADH
Acetoacetyl-CoA
3-Hydroxybutyryl-Coenzyme A
Omega-3-carboxylic acids
Diseases
Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS
Alcohol consumption (drinks per week) (
30643258
)
Alcohol dependence (
23456092
33290381
)
Regular attendance at a pub or social club (
29970889
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Interacting Genes
2 interacting genes:
CSNK2A2
HADH
8 interacting genes:
ADH1A
APP
CDC42
CLK1
FBXL17
FBXO7
SLC2A4
STAT1
Entrez ID
124
3033
HPRD ID
00063
08372
Ensembl ID
ENSG00000187758
ENSG00000138796
Uniprot IDs
P07327
A0A0D9SFP2
A0A140VK76
B3KTT6
Q16836
PDB IDs
1HSO
1U3T
1F0Y
1F12
1F14
1F17
1IL0
1LSJ
1LSO
1M75
1M76
2HDH
3HAD
3RQS
Enriched GO Terms of Interacting Partners
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Liver Development
Metanephric Cortical Collecting Duct Development
Metanephric Cortex Development
Metanephric Distal Tubule Development
Wnt Signaling Pathway
Protein Kinase CK2 Complex
Gland Development
Metanephric Part Of Ureteric Bud Development
Calcium-induced Calcium Release Activity
Migrasome
Polycystin Complex
Metanephric Smooth Muscle Tissue Development
Metanephric Ascending Thin Limb Development
Renal Artery Morphogenesis
Distal Tubule Development
Cellular Response To Hydrostatic Pressure
Basal Cortex
HLH Domain Binding
Nephric Duct Development
Mesonephric Duct Development
Metanephric S-shaped Body Morphogenesis
Detection Of Nodal Flow
(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
S-shaped Body Morphogenesis
Determination Of Liver Left/right Asymmetry
Response To Hydrostatic Pressure
Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Metanephric Mesenchyme Development
Voltage-gated Monoatomic Cation Channel Activity
Response To Water
Voltage-gated Monoatomic Ion Channel Activity
Male Gamete Generation
Spermatogenesis
Regulation Of Establishment Of Protein Localization
Gamete Generation
Muscle Alpha-actinin Binding
Metanephric Epithelium Development
Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Cation Channel Complex
Voltage-gated Sodium Channel Activity
Renal Tubule Morphogenesis
Protein Heterotetramerization
Metanephric Tubule Development
Outward Rectifier Potassium Channel Activity
Actinin Binding
Metanephric Nephron Tubule Development
NAD+ Binding
Centrosome Duplication
Smooth Muscle Tissue Development
Nephron Tubule Development
Butanol Dehydrogenase (NAD+) Activity
Amyloid-beta Complex
Growth Cone Lamellipodium
Neuron Projection Organization
Cellular Developmental Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Response To Calcium Ion
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Response To Peptide
Clathrin-coated Pit
Protein-containing Complex
Response To Cytokine
Regulation Of Nitric Oxide Metabolic Process
Positive Regulation Of Nitric Oxide Metabolic Process
Circulatory System Process
Cellular Response To Type II Interferon
Amylopectin Biosynthetic Process
D-glucose Uniporter Activity
Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Body Corona
SCF Ubiquitin Ligase Complex
Lewy Neurite
Regulation Of Signal Transduction
Acetylcholine Receptor Activator Activity
PTB Domain Binding
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Dendrite
Endosome To Plasma Membrane Transport Vesicle
Positive Regulation Of Endothelin Production
Growth Cone Filopodium
Lipoprotein Particle
Memory
Regulation Of Mitotic Cell Cycle
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Regulation Of Cell Communication
Positive Regulation Of Protein Import
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
Response To CAMP
Regulation Of Signaling
Response To Type II Interferon
Endothelin Receptor Signaling Pathway Involved In Heart Process
Cellular Response To Cytokine Stimulus
GBD Domain Binding
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Tagcloud (Difference)
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Tagcloud (Intersection)
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