ADH1A and HADH

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADH1A	HADH
Gene Name		alcohol dehydrogenase 1A (class I), alpha polypeptide	hydroxyacyl-CoA dehydrogenase
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Alcohol Dehydrogenase (NAD) Activity Alcohol Dehydrogenase Activity, Zinc-dependent Protein Binding Zinc Ion Binding	3-hydroxyacyl-CoA Dehydrogenase Activity NAD+ Binding
	Biological Process	Alcohol Metabolic Process Ethanol Oxidation Xenobiotic Metabolic Process Drug Metabolic Process Small Molecule Metabolic Process	Fatty Acid Beta-oxidation Response To Activity Response To Insulin Response To Drug Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Ethanol oxidation Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations RA biosynthesis pathway Abacavir transport and metabolism Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Signaling by Retinoic Acid Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Abacavir metabolism Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Fatty acid, triacylglycerol, and ketone body metabolism Beta oxidation of octanoyl-CoA to hexanoyl-CoA Metabolism of lipids and lipoproteins Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Mitochondrial Fatty Acid Beta-Oxidation Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA mitochondrial fatty acid beta-oxidation of saturated fatty acids Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs		NADH Ethanol Fomepizole Nicotinamide-Adenine-Dinucleotide 4-Iodopyrazole N-Cyclopentyl-N-Cyclobutylformamide	NADH Nicotinamide-Adenine-Dinucleotide Acetoacetyl-Coenzyme A 3-Hydroxybutyryl-Coenzyme A
Diseases
GWAS		Alcohol dependence ( 23456092)
Protein-Protein Interactions		2 interactors: CSNK2A2 HADH	4 interactors: ADH1A APP SLC2A4 STAT1
Entrez ID		124	3033
HPRD ID		00063	08372
Ensembl ID		ENSG00000187758	ENSG00000138796
Uniprot IDs		P07327	E9PF18 Q16836
PDB IDs		1HSO 1U3T	1F0Y 1F12 1F14 1F17 1IL0 1LSJ 1LSO 1M75 1M76 2HDH 3HAD 3RQS
Enriched GO Terms of Interacting Partners?		Cardiolipin Acyl-chain Remodeling Cardiolipin Metabolic Process Negative Regulation Of Insulin Secretion Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Negative Regulation Of Peptide Secretion Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Fatty Acid Beta-oxidation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Response To Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hormone Secretion Negative Regulation Of Proteasomal Protein Catabolic Process Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of Protein Secretion	Negative Regulation Of Macrophage Fusion Amylopectin Biosynthetic Process Chemical Homeostasis Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Synaptic Growth At Neuromuscular Junction Response To Abiotic Stimulus Cellular Response To Insulin Stimulus Collateral Sprouting In Absence Of Injury Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Homeostatic Process Collateral Sprouting Axon Midline Choice Point Recognition Metanephric Mesenchymal Cell Differentiation Response To Insulin Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Axon Choice Point Recognition Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Cellular Response To Peptide Negative Regulation Of Cell Development Alcohol Metabolic Process Glucose Import Neuron Remodeling Mesenchymal Cell Differentiation Involved In Kidney Development Cell Proliferation Involved In Metanephros Development Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Response To Oxidative Stress Cell Differentiation Involved In Metanephros Development Response To Peptide Hormone Cellular Response To Organonitrogen Compound Cellular Response To Interferon-beta Response To Peptide Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Ethanol Oxidation Metanephric Mesenchyme Development Cellular Copper Ion Homeostasis Response To Interferon-beta Regulation Of Nephron Tubule Epithelial Cell Differentiation Cellular Response To Hormone Stimulus Small Molecule Metabolic Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Epithelial Cell Differentiation Involved In Kidney Development JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Copper Ion Homeostasis
Tagcloud ?		4r a5 alcoholic aldehyde aldh1l1 anxa5 bcl2a1 bcl2l2 cirrhosis gadd45a ifngr2 il2rb il4 myeloperoxidase natriuretic nfkappabeta nfkb nibp nkiras2 nox5 nppa peroxisomal pex5 pparg tank tegt tnfrsf9 traf ttrap	aeruginosa brown colorimetric concurrently dehydrogenases dinitrophenylhydrazine easily enantioselective enantioselectivity hadhs harboring herein hplc hydroxyacid hydroxyacids industry isolate isolation ketoacid matches microorganisms oxidation producing pseudomonas quantified spectrophotometric stains throughput true
Tagcloud (Difference) ?		4r a5 alcoholic aldehyde aldh1l1 anxa5 bcl2a1 bcl2l2 cirrhosis gadd45a ifngr2 il2rb il4 myeloperoxidase natriuretic nfkappabeta nfkb nibp nkiras2 nox5 nppa peroxisomal pex5 pparg tank tegt tnfrsf9 traf ttrap	aeruginosa brown colorimetric concurrently dehydrogenases dinitrophenylhydrazine easily enantioselective enantioselectivity hadhs harboring herein hplc hydroxyacid hydroxyacids industry isolate isolation ketoacid matches microorganisms oxidation producing pseudomonas quantified spectrophotometric stains throughput true
Tagcloud (Intersection) ?