GSTK1 and PRPF19

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GSTK1	PRPF19
Gene Name		glutathione S-transferase kappa 1	pre-mRNA processing factor 19
Image
Gene Ontology Annotations	Cellular Component	Intracellular Mitochondrial Inner Membrane Mitochondrial Matrix Peroxisome Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Lipid Particle Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Receptor Binding Protein Disulfide Oxidoreductase Activity	Protein Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Glutathione Metabolic Process Epithelial Cell Differentiation Oxidation-reduction Process	Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation Double-strand Break Repair Via Nonhomologous End Joining RNA Splicing Lipid Biosynthetic Process Gene Expression Proteasomal Protein Catabolic Process Cellular Protein Localization Negative Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination Signal Transduction Involved In DNA Damage Checkpoint
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs		Glutathione GLUTATHIONE SULFINATE
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CCNDBP1 FAM9B GRB2 PEX5 PIP4K2A PRPF19	17 interactors: BCAS2 CDC5L DDX42 DNTT EGLN3 EXOC7 GSTK1 HSPB1 POLR2A PRCC PRPF8 PSMB4 RPA1 RPA2 RPA3 U2AF1 UBE2D3
Entrez ID		373156	27339
HPRD ID		13613	12214
Ensembl ID		ENSG00000197448	ENSG00000110107
Uniprot IDs		E9PFN5 Q6FII1 Q9Y2Q3	Q9UMS4
PDB IDs		1YZX 3RPN 3RPP	4LG8
Enriched GO Terms of Interacting Partners?		Signal Transduction In Response To DNA Damage Generation Of Catalytic Spliceosome For First Transesterification Step Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Lipid Modification Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Protein Homooligomerization Lipid Metabolic Process Protein Import Into Peroxisome Membrane Protein To Membrane Docking Peroxisomal Membrane Transport Regulation Of Protein Complex Assembly Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Protein Oligomerization Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Generation Of Neurons Protein Import Into Peroxisome Matrix Spliceosomal Tri-snRNP Complex Assembly Neurogenesis Megakaryocyte Development Protein Oligomerization Cell Development System Development In Utero Embryonic Development Cellular Component Assembly Inner Cell Mass Cell Proliferation Double-strand Break Repair Via Nonhomologous End Joining Megakaryocyte Differentiation Labyrinthine Layer Morphogenesis Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Lipid Biosynthetic Process Very Long-chain Fatty Acid Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Embryonic Placenta Morphogenesis Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Blastocyst Growth Regulation Of Astrocyte Differentiation Multicellular Organismal Development Protein K63-linked Ubiquitination Positive Regulation Of RNA Splicing Anatomical Structure Development Nervous System Development	DNA Recombinase Assembly Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleotide-excision Repair Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Repair RNA Splicing Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle DNA Metabolic Process Nitrogen Compound Metabolic Process MRNA Processing Mismatch Repair Base-excision Repair Cellular Response To Heat Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair MRNA Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition RNA Processing Cell Cycle Process DNA-dependent DNA Replication Response To Heat Heterocycle Metabolic Process Mitotic Cell Cycle Process DNA Catabolic Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Double-strand Break Repair Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Protein-DNA Complex Assembly Response To Stress Cell Cycle
Tagcloud ?			beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Difference) ?			beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Intersection) ?