SHMT1 and SULT1A3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SHMT1	SULT1A3
Description		serine hydroxymethyltransferase 1	sulfotransferase family 1A member 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Intracellular Organelle Lumen Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity Glycine Hydroxymethyltransferase Activity Protein Binding Transferase Activity Aldehyde-lyase Activity Pyridoxal Phosphate Binding Small Molecule Binding Identical Protein Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Serine Binding	Aryl Sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity Sulfate Binding Amine Sulfotransferase Activity
	Biological Process	DTMP Biosynthetic Process Regulation Of Translation Glycine Metabolic Process L-serine Metabolic Process L-serine Catabolic Process One-carbon Metabolic Process Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Carnitine Biosynthetic Process Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Homotetramerization Cellular Response To Tetrahydrofolate Cellular Response To Leukemia Inhibitory Factor	Ethanol Catabolic Process Catecholamine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Flavonoid Metabolic Process Thyroid Hormone Metabolic Process Epinephrine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Dopamine Catabolic Process Serotonin Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation Cellular Response To Dopamine
Pathways		Metabolism of folate and pterines Carnitine synthesis	Cytosolic sulfonation of small molecules XBP1(S) activates chaperone genes Paracetamol ADME
Drugs		Pyridoxal phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-formyl-tetrahydrofolate 5-hydroxymethyl-5,6-dihydrofolic acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Blood protein levels ( 30072576) Change in neurofilament light levels ( 31295725) Multiple sclerosis ( 27386562) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: CSNK2B DDX6 DEDD DLEU1 FBXO7 GORASP2 MAPK9 MDFI PIM1 PRSS23 SULT1A3	6 interacting genes: APP KHDRBS2 NIF3L1 SHMT1 SMN1 TK1
Entrez ID		6470	6818
HPRD ID		01643	07199
Ensembl ID		ENSG00000176974	ENSG00000261052
Uniprot IDs		P34896	P0DMM9 Q1ET61
PDB IDs		1BJ4 6FL5 6M5W 7RJL 7RJP 8A11 8R7H	1CJM 2A3R
Enriched GO Terms of Interacting Partners?			Protein Tetramerization Deoxyribonucleoside Monophosphate Biosynthetic Process Protein Homooligomerization Protein Complex Oligomerization Identical Protein Binding Nucleoside Monophosphate Biosynthetic Process Pyrimidine-containing Compound Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Aldehyde-lyase Activity Cellular Response To Tetrahydrofolate Protein Homotetramerization Pyrimidine-containing Compound Metabolic Process Nucleoside Monophosphate Metabolic Process Protein-containing Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Perikaryon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Carnitine Biosynthetic Process Glycine Hydroxymethyltransferase Activity Glycine Biosynthetic Process From Serine DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Glycine Biosynthetic Process DTMP Biosynthetic Process L-serine Catabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?