SERPINE2 and COL4A4

Number of citations of the paper that reports this interaction (PMID 8006028)
4

Data Source:
HPRD (in vivo)

		SERPINE2	COL4A4
Gene Name		serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	collagen, type IV, alpha 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Extracellular Matrix Platelet Alpha Granule Extrinsic Component Of External Side Of Plasma Membrane Neuromuscular Junction Vesicle	Extracellular Region Collagen Type IV Trimer Basal Lamina Endoplasmic Reticulum Lumen
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding	Extracellular Matrix Structural Constituent
	Biological Process	Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cerebellar Granular Layer Morphogenesis Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation	Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Glomerular Basement Membrane Development
Pathways		Common Pathway Intrinsic Pathway Dissolution of Fibrin Clot Formation of Fibrin Clot (Clotting Cascade)	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065) Height ( 20881960)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		9 interactors: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F2 FAM9B PLAU	12 interactors: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 TGFBI
Entrez ID		5270	1286
HPRD ID		01510	00360
Ensembl ID		ENSG00000135919	ENSG00000081052
Uniprot IDs		P07093	P53420
PDB IDs		4DY0 4DY7
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Chemotaxis Locomotion Movement Of Cell Or Subcellular Component Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Generation Of Neurons Neuron Projection Development Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Catabolic Process Response To External Stimulus Neuron Development Cell Morphogenesis Glomerular Basement Membrane Development Neuron Differentiation Cell Projection Organization Nervous System Development Fibrinolysis Cell Development Neuromuscular Junction Development Renal System Development Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Glomerulus Development Cell Differentiation Negative Regulation Of Wound Healing Urogenital System Development Negative Regulation Of Angiogenesis Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Blood Coagulation System Development Regulation Of Wound Healing Endothelial Cell Apoptotic Process Regulation Of Smooth Muscle Cell-matrix Adhesion Nephron Development Multicellular Organismal Development Synapse Organization	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Response To Wounding Wound Healing Endodermal Cell Differentiation Acute-phase Response Leukocyte Migration Regulation Of Cell Adhesion Peptide Cross-linking Endoderm Formation Seminal Vesicle Epithelium Development Dendrite Regeneration Anatomical Structure Morphogenesis Cell Migration Acute Inflammatory Response Cell Motility Endoderm Development Negative Regulation Of Transport Tissue Development Negative Regulation Of Ion Transport Mating Plug Formation Blood Coagulation Hemostasis Response To External Stimulus Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein System Development Formation Of Primary Germ Layer Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Receptor Binding Calcium-independent Cell-matrix Adhesion Cell Adhesion Positive Regulation Of Keratinocyte Migration Negative Regulation Of Plasminogen Activation Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Body Fluid Levels Locomotion Immune System Process Chemotaxis Regulation Of Growth Reproductive Process Nervous System Development Multicellular Organismal Development Response To Stress Gastrulation Platelet Activation Cell Activation Negative Regulation Of Platelet Aggregation Tyrosine Phosphorylation Of STAT Protein
Tagcloud ?		adulthood alters antagonize cerebellar cerebellum cgnp cgnps enlarged enlargement exit gli1 granular hedgehog interferes lobes lrps mitogenic morphogens nexin outer overactivation pn protease relies shaping shh sonic tight	alport basement clarification classic diagnostics families focal fsgs gbm glomerulosclerosis hematuria hereditary heterozygous histologic illustrates inconsistent inherited interpretation nephritis nephropathy nephrotic pathognomonic predominant proteinuria segmental segregated thin variants
Tagcloud (Difference) ?		adulthood alters antagonize cerebellar cerebellum cgnp cgnps enlarged enlargement exit gli1 granular hedgehog interferes lobes lrps mitogenic morphogens nexin outer overactivation pn protease relies shaping shh sonic tight	alport basement clarification classic diagnostics families focal fsgs gbm glomerulosclerosis hematuria hereditary heterozygous histologic illustrates inconsistent inherited interpretation nephritis nephropathy nephrotic pathognomonic predominant proteinuria segmental segregated thin variants
Tagcloud (Intersection) ?