SERPINE2 and ETS2

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		SERPINE2	ETS2
Name		serpin family E member 2	ETS proto-oncogene 2, transcription factor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Extracellular Matrix Platelet Alpha Granule Neuromuscular Junction Extracellular Vesicle	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Peptidase Inhibitor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nervous System Development Blood Coagulation Negative Regulation Of Cell Population Proliferation Response To Wounding Negative Regulation Of Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Protein Processing Cerebellar Granular Layer Morphogenesis Cell Differentiation Protein Catabolic Process Platelet Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Dissolution of Fibrin Clot	Oncogene Induced Senescence
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065 ) Blood protein levels ( 30072576 ) Cerebrospinal T-tau levels ( 28247064 ) Cytokine levels ( 31679650 ) Cytokine network levels (multivariate analysis) ( 31679650 ) Height ( 20881960 31562340 ) Inflammatory biomarkers (multivariate analysis) ( 33110245 ) Mean platelet volume ( 27863252 32888494 ) Platelet-derived growth factor BB levels ( 27989323 )	Adult body size ( 32376654 ) Body mass index ( 25673413 ) Body size at age 10 ( 32376654 ) C-reactive protein levels ( 30388399 ) Central corneal thickness ( 32528159 ) Eye morphology ( 29921221 ) Fibrinogen levels ( 28107422 ) Finger osteoarthritis severity (hand Klsum) ( 33055079 ) Fractures ( 30158200 ) Intraocular pressure ( 29617998 ) Non-small cell lung cancer (survival) ( 21079520 ) Periodontitis (Mean PAL) ( 24024966 ) Schizophrenia ( 30285260 ) Serum alkaline phosphatase levels ( 33547301 ) TPE interval (response to exercise) ( 32386560 )
Novel Interactors		None recorded	2 novel interactors: HMGN1 SLC71A2
Interacting Genes		9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ETS2 F2 FAM9B	37 interacting genes: CDK10 CLU COP1 CREBBP DAD1 DMXL2 EGLN2 EP300 ERG ETS1 FOCAD FOS GABRD GATA3 GTF3C4 JUN NCOR1 NDRG1 NDUFB5 NR3C1 POU5F1 PPME1 RPL15 SERPINE2 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 TERF2IP TTC3 UBC USP7 ZBTB44 ZFYVE9 ZMYND11
Entrez ID		5270	2114
HPRD ID		01510	01263
Ensembl ID		ENSG00000135919	ENSG00000157557
Uniprot IDs		P07093	P15036
PDB IDs		4DY0 4DY7	4BQA 4MHV
GO Terms Enriched among Interactors		Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Extracellular Matrix Structural Constituent Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Extracellular Region Glomerular Basement Membrane Development Cell Surface Receptor Signaling Pathway Neuromuscular Junction Development Cellular Response To Amino Acid Stimulus Ectodermal Cell Fate Commitment Response To Amino Acid Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Thrombospondin Receptor Activity Neutrophil-mediated Killing Of Gram-negative Bacterium Retinal Blood Vessel Morphogenesis Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway	Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Chromatin Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding DNA Binding Myeloid Cell Differentiation Chromatin Organization Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Histone H3K27 Acetyltransferase Activity Positive Regulation Of Leukocyte Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Pro-T Cell Differentiation Mononuclear Cell Differentiation Host-mediated Activation Of Viral Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Cell Activation Response To Stress Myeloid Leukocyte Activation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lymphocyte Differentiation Regulation Of Cell-cell Adhesion DNA-binding Transcription Factor Activity Transcription Regulator Complex Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Leukocyte Differentiation